舒脑欣滴丸治疗血虚血瘀型慢性脑供血不足的临床观察

目的]研究舒脑欣滴丸对血虚血瘀型慢性脑供血不足的临床疗效。方法]将100例符合纳入标准的慢性脑供血不足患者随机分为两组,治疗组(舒脑欣滴丸)50例、对照组(尼莫地平)50例。治疗4周后观察证候评分、经颅多普勒(TCD)、血流变的变化。结果]1)中医症状评分及疗效上,两组脑供血不足中医症状评分均明显低于治疗前(均P0.05),治疗组总有效率显著高于对照组(P0.05)。两组失眠症状评分均明显低于治疗前(P0.05),治疗组总有效率显著高于对照组(P0.05)。2)脑血流改善方面,经颅多普勒结果检测治疗组双侧大脑中动脉(MCA)及双侧基底动脉(BA)治疗后搏动指数(PI)降低,与治疗前比较有统计学差异(P0.05),且治疗组左侧大脑中动脉(LMCA)及双侧基底动脉(BA)的搏动指数(PI)与对照组比较亦有统计学差异(P0.05)。血流速度增快两组间比较,对照组有效率高于治疗组,有统计学差异(P0.05);血流速度减慢两组间比较无统计学意义(P0.05)。结论]舒脑欣滴丸可明显改善血虚血瘀型慢性脑供血不足患者临床症状,能够双向调节脑血流速度,提高血管顺应性,提高脑灌注。

Clinical research of Shunaoxin dropping pills on chronic cerebral circulation insufficiency

Objective] To study the clinical effects of Shunaoxin dropping pills on blood deficiency and blood stasis syndrome of chronic cerebral circulation. Methods] The 100 patients met the inclusion criteria of chronic cerebral circulation insufficiency were randomly divided into two groups, the treatment group 50 cases (Shunaoxin dropping pills), control group (nimodipine) of 50 cases. Changes of symptom score, transcranial doppler (TCD), blood flow after 4 weeks were observed. Results] 1) About clinical symptoms score and efficacy, two groups of cerebral blood deficiency symptom score were significantly lower than those before treatment (P<0.05). The total effective rate of treatment group was significantly higher than that in control group (P<0.05). Two groups of insomnia symptoms score were significantly lower than that before treatment (P<0.05), and the total effective rate of treatment group was significantly higher than that in control group (P<0.05). 2) About improvement of cerebral blood flow, pulsatility index (PI) decreased the TCD detection results of middle cerebral artery (MCA) and basilar artery (BA) in treatment group after treatment. There were significant differences compared with those before treatment (P<0.05), and the treatment group left MCA and BA PI in comparison with the control group, and there were significant differences (P<0.05). Flow rate between the two left groups, the control group had higher efficiency than the treatment group, and there was obvious difference (P<0.05). Blood flow velocity showed no statistical significance between the two groups (P>0.05). Conclusion] Shunaoxin dropping pills can obviously improve the clinical symptoms in patients with chronic cerebral circulation insufficiency of blood deficiency and blood stasis, capable of bidirectional regulation of cerebral blood flow velocity, improve vascular compliance, improve cerebral perfusion