| 益母草中脂肪族化合物的研究 |
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| 引用本文： | 周勤梅,彭成,蒙春旺,刘露丝,杨雨婷,郭力,熊亮,刘昭华. 益母草中脂肪族化合物的研究[J]. 中草药, 2015, 46(9): 1283-1286 |
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| 作者姓名： | 周勤梅 彭成 蒙春旺 刘露丝 杨雨婷 郭力 熊亮 刘昭华 |
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| 作者单位： | 1. 成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都,611137
2. 成都第一药业有限公司,四川成都61003l |
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| 基金项目： | 国家自然科学基金资助项目(81303209);中国博士后科学基金项目(2014M562291);四川省应用基础研究项目(2012JYZ005);四川省科技支撑计划(2011SZ0056) |
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| 摘 要： | 目的研究益母草Leonurus japonicus的低极性化学成分。方法采用硅胶、Sephadex LH-20以及反相C_(18)柱色谱-等方法进行分离纯化,根据理化性质及波谱数据鉴定化合物结构。结果从益母草的醋酸乙酯提取部位分离得到6个化合物,包括叠烯类化合物2个:(-)-十九碳-5,6-二烯酸甲酯(1)、十八碳-5,6-二烯酸甲酯(2);饱和脂肪族化合物4个:二十一烷酸(3)、花生酸(4)、二十七烷酸(5)和肉豆蔻酸甲酯(6)。结论所有化合物均为首次从益母草中分离得到,其中化合物1为新化合物,命名为益母草叠烯酸酯A,化合物2为首次从益母草属植物中分离得到。
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| 关 键 词： | 益母草 脂肪族化合物 叠烯 益母草叠烯酸酯A 十八碳-5,6-二烯酸甲酯 肉豆蔻酸甲酯 |
| 收稿时间： | 2015-01-08 |
Aliphatic compounds from Leonurus japonicus |
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| ZHOU Qin-mei,PENG Cheng,MENG Chun-wang,LIU Lu-si,YANG Yu-ting,GUO Li,XIONG Liang and LIU Zhao-hua. Aliphatic compounds from Leonurus japonicus[J]. Chinese Traditional and Herbal Drugs, 2015, 46(9): 1283-1286 |
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| Authors: | ZHOU Qin-mei PENG Cheng MENG Chun-wang LIU Lu-si YANG Yu-ting GUO Li XIONG Liang LIU Zhao-hua |
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| Affiliation: | State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu No. 1 Pharmaceutical Co., Ltd., Chengdu 610031, China |
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| Abstract: | Objective To study the low polar chemical constituents from Leonurus japonicus. Methods The chemical constituents were isolated and purified by various chromatographic methods including column chromatography over silica, Sephadex LH-20, and Rp C18 columns. Their structures were identified by physicochemical properties and spectroscopic analysis. Results Six aliphatic compounds were isolated from the EtOAc extracts of L. japonicus, including two allenes: (-)-nonadeca-5,6-dienoic acid methyl ester (1) and methyl octadeca-5,6-dienoate (2); four saturated aliphatic compounds: heneicosanoic acid (3), arachidic acid (4), heptacosanoic acid (5), and methyl myristate (6). Conclusion All the compounds are isolated from L. japonicus for the first time. Compound 1 is a new one named leonuallenote A, while compound 2 is first reported from the plants of Leonurus L. |
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| Keywords: | Leonurus japonicus Houtt. aliphatic compounds allenes leonuallenote A methyl octadeca-5,6-dienoate methyl myristate |
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