| 中药逆转MCF-7/ADM细胞多药耐药机制的研究进展 |
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| 引用本文： | 曾青青,王鹏,潘桂湘,王晓明,王春华. 中药逆转MCF-7/ADM细胞多药耐药机制的研究进展[J]. 天津中医药, 2015, 32(4): 253-256 |
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| 作者姓名： | 曾青青 王鹏 潘桂湘 王晓明 王春华 |
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| 作者单位： | 天津中医药大学, 天津市现代重点实验室-省部共建国家重点实验室培育基地, 天津 300193;天津国际生物医药联合研究院, 天津 300457,天津中医药大学, 天津市现代重点实验室-省部共建国家重点实验室培育基地, 天津 300193;天津国际生物医药联合研究院, 天津 300457,天津中医药大学, 天津市现代重点实验室-省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 天津市现代重点实验室-省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 天津市现代重点实验室-省部共建国家重点实验室培育基地, 天津 300193 |
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| 基金项目： | 国家自然科学基金项目(81001633, 81173523, 81303182);天津市自然基金项目(13JCZDJC28600). |
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| 摘 要： | 乳腺癌细胞(MCF-7/ADM)的多药耐药性(MDR)是导致抗肿瘤药物临床化疗失败的主要原因。现认为细胞中的P-gp、Bcl-2、GST-π、TopoⅡ等蛋白可能与乳腺癌的多药耐药相关。近年来研究发现,不少中药能够下调MDR1 mRNA和/或P-gp的表达,从而逆转MCF-7/ADM细胞对抗肿瘤药物的多药耐药性,提高耐药细胞对化疗药物敏感性。主要对MCF-7/ADM细胞的多药耐药机制及有逆转MCF-7/ADM多药耐药作用的中药进行了综述。
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| 关 键 词： | 中药 MCF-7/ADM 多药耐药 P-gp |
| 收稿时间： | 2014-12-19 |
Development in reversing mechanism of MCF-7/ADM cell multidrug resistance by traditional Chinese medicine |
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| ZENG Qing-qing,WANG Peng,PAN Gui-xiang,WANG Xiao-ming and WANG Chun-hua. Development in reversing mechanism of MCF-7/ADM cell multidrug resistance by traditional Chinese medicine[J]. Tianjin Journal of Traditional Chin Medicine, 2015, 32(4): 253-256 |
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| Authors: | ZENG Qing-qing WANG Peng PAN Gui-xiang WANG Xiao-ming WANG Chun-hua |
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| Affiliation: | Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China and Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | traditional Chinese medicine MCF-7/ADM cell multidrug resistance P-gp |
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