| 栀芪降糖饮对2型糖尿病大鼠胰岛素抵抗及脂肪细胞因子的影响 |
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| 引用本文： | 刘珈,王德惠,李晋宏,杜瑞斌,王海英,李春岭,扈丽萍,张晓莉,富利燕,张立伟. 栀芪降糖饮对2型糖尿病大鼠胰岛素抵抗及脂肪细胞因子的影响[J]. 天津中医药, 2015, 32(4): 224-228 |
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| 作者姓名： | 刘珈 王德惠 李晋宏 杜瑞斌 王海英 李春岭 扈丽萍 张晓莉 富利燕 张立伟 |
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| 作者单位： | 天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150,天津中医药大学第二附属医院内分泌科, 天津 300150 |
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| 基金项目： | 国家中医药管理局全国名老中医药专家传承工作室建设项目;第四批全国老中医药专家学术经验继承工作项目。 |
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| 摘 要： | [目的]探讨名老中医经验方栀芪降糖饮改善2型糖尿病胰岛素抵抗(IIR)的作用机制。[方法]50只雄性SD大鼠采用高脂高糖饲料加小剂量链脲佐菌素(STZ)腹腔注射造模。观察栀芪降糖饮对实验性2型糖尿病胰岛素抵抗大鼠空腹血糖(FPG)、空腹胰岛素(FINS)、血脂包括甘油三酯(TC)、胆固醇(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、胰岛素敏感指数(ISI)、胰岛素抵抗指数(HOMA-IR)、血清脂肪细胞因子包括脂联素、肿瘤坏死因子-α(TNF-α)、抵抗素、游离脂肪酸(FFA)水平的影响,以及对各组大鼠胰腺病理改变的影响。[结果]栀芪降糖饮高、低剂量组均能调节血糖和血清胰岛素水平,提高ISI,降低HOMA-IR;能够调节血脂紊乱,增加血清脂联素含量,降低血清FFA、TNF-α、抵抗素水平,并且对大鼠胰腺病理改变有不同程度修复与改善,其作用水平与阳性对照药物吡格列酮相当,与模型组比较有统计学差异(P0.05)。[结论]栀芪降糖能够改善2型糖尿病大鼠胰岛素抵抗,用药安全可靠,值得临床推广。
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| 关 键 词： | 2型糖尿病 胰岛素抵抗 实验研究 脂肪细胞因子 栀芪降糖饮 |
| 收稿时间： | 2014-12-20 |
Influence of Ziqi Jiangtang Yin to type 2 diabetes mellitus rats insulin resistance and adipocytokines |
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| LIU Ji,WANG De-hui,LI Jin-hong,DU Rui-bin,WANG Hai-ying,LI Chun-ling,HU Li-ping,ZHANG Xiao-li,FU Li-yan and ZHANG Li-wei. Influence of Ziqi Jiangtang Yin to type 2 diabetes mellitus rats insulin resistance and adipocytokines[J]. Tianjin Journal of Traditional Chin Medicine, 2015, 32(4): 224-228 |
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| Authors: | LIU Ji WANG De-hui LI Jin-hong DU Rui-bin WANG Hai-ying LI Chun-ling HU Li-ping ZHANG Xiao-li FU Li-yan ZHANG Li-wei |
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| Affiliation: | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China,Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China and Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China |
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| Abstract: | |
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| Keywords: | T2DM insulinresistance experiment research adipocytokines Zhiqi Jiangtang Yin |
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