Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy |
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Authors: | Glauser Tracy A |
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Affiliation: | Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. glauser@cchmc.org |
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Abstract: | The three goals of this article are (1) to delineate the limitations in determining the actual incidence of antiepileptic drug (AED) psychiatric and behavioral side effects; (2) to summarize existing data on the direct effects of AEDs on psychiatric and behavioral comorbidities and examine the relationship between these direct effects and specific AED mechanisms of action; and (3) to recognize the indirect effects of AEDs on psychiatric and behavioral medications that can result in aggravation of these comorbidities through drug-drug interactions. All of these data are then combined and formatted into a practical algorithm useful in many clinical situations. |
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