三联治疗对难治性贫血及慢性再生障碍性贫血疗效观察

目的：应用三联疗法治疗骨髓增生异常综合征难治性贫血（ＭＤＳ－ＲＡ）与慢性再生障碍性贫血，观察其疗效。方法：应用全反式维甲酸，活性维生素Ｄ３及康力龙三联药物治疗３０例ＭＤＳ－ＲＡ及１０例ＣＡＡ患者。结果：三联药物治疗后ＭＤＳ－ＲＡ的有效率９６．６％，完全缓解率４３．３％，疗效持久，平均随访２年无１例转化为急性白血病，而ＣＡＡ用上述三联治疗平均２３ｄ时均因病情加重而终止治疗。

Observations on the differentiation between refractory anemia and chronic aplastic anemia by triad therapy

Objective:Obseration on the effect of tviad therapy,on refaitory anemia of myelodys plasia and chronic aplastic anemia by applying all trans Retinoic Acid (ATRA), 1.25 dihydroxyvitamin D 3 ( 1.25 D 3) and androgen to the therapy.Method:30 patients of MDS RA and 10 of CAA were treated by ATRA, 1.25 vitamin D 3 and androgen.Result:After triad therapy,it had taken effect on MDS RA,the total rate of efficacy was 96.6 %,and rate of complete remission was 43.3 %. During the process of continual administration,the general status of patients were good. In contrast,All these 10 patients with CAA had to quit ATRA after 23 days of triad therapy for the progress of decrease and exacerbation of the.Conclusion:The results of our research showed that the combinative administration of ATRA, 1.25 D 3 and androgen had obvious effects on MDS RA but no effects on CAA.