Patch test reactions to mite antigens: a GERDA* multicentre study |
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| Authors: | Michel,Castelain ,Joö lle,Birnbaum Pierre-Yves, Castelain ,Georges,Ducombs ,Edouard,Grosshans ,Gilbert,Jelen ,Michel,Lacroix ,Janine,Meynadier ,Jean-Marie, Mougeolle ,Jean-Marie, Lachapelle ,Jacques,Oleffe ,Annick,Pons ,Alain,Taieb ,Dominique,Tennstedt ,Daniel,Vervloet |
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| Affiliation: | Groupe d'Etudes et de Recherches en Dermato-Allergic;Service de Dermatologic, Hôpital Saite- Marguerite. F-13277 Marseille Cedex 9, France;Service de Phenumo-Allergologic, Hôpital Sainte-Marguerite, F-13277 Marseille Cedex 9, France;Clinique Dermatolgique, I place Amélie-Raba-Léon, F-33076 Bordeaux Cedex, France;Clinique Dermatologique, I Place de I'Hôpital, F-67091 Strasbourg Cedex, France;Hôpital Civil F-67700 Saverne, France;Hôpital du Bocage, F-21000 Dijion, France;Clinque Dermatologique, Hôpital Saint- Charles. F-34000 Montpellier, France;Service de Dermatologic, Hôpital Fournier, 34 Quai de la Bataille, F-54000 Nancy, Frane;Unite de Dermatologic Professionnelle, Ecole de Sante Publique, 30 Clos Chapelle aux Champs, B-1200 Bruxelles, Belgium;234 Avenue du Kouter, B-1134 Bruxelles, Belgium;Service de Dermatologie, Hôpital Saint-Louis, I Avenue Claude Vellefaux, F-75475 Paris Cedex 10, France |
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| Abstract: | We performed patch tests with Dermatophagoides pteronyssinus (Dp) antigen from 2 different sources in 355 non-randomly selected patients with atopic dermatitis(AD) and 398 subjects of a control group. The study demonstrated that contact sensitization to mites occurred in an appreciable% of AD cases(20.8%). Using commonly available assay products. The differences recorded between the 2 materials tested were related to the concentration of P1 antigen. Non-atopic patients rarely showed positive reactions to Dp (0.75%), when strict criteria for readings were applied and if 2 readings were performed, Patients with positive patch tests did not necessarily show positive immediate skin tests. It would be useful to carry out tests systematically in atopic patients, even if it is not yet known what modern treatment would be best for the patient. Laboratories still do not provide standardized house dust mite preparations measuring and codifying their biological acitivity for use in patch of better test materials, in syringes with homogeneous dispersion and concentration. |
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| Keywords: | inhalant allergens PI antigen atopic dermatitis mite antigen patch testing technique |
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