| 丝裂原活化蛋白激酶信号途径在心肌肥厚中的作用进展 |
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| 引用本文： | 黄朝阳,朱建华. 丝裂原活化蛋白激酶信号途径在心肌肥厚中的作用进展[J]. 中国病理生理杂志, 2005, 21(7): 1435-1439. DOI: 1000-4718 |
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| 作者姓名： | 黄朝阳 朱建华 |
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| 作者单位： | 浙江大学医学院附属第一医院心内科,浙江,杭州,310003 |
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| 基金项目： | 浙江省科技厅资金资助项目(No.021107057) |
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| 摘 要： | Myocardial hypertrophy is an independent risk factor for cardiac events. Mitogen-activated protein kinases(MAPK), including extracellular signal-regulated kinases, C-jun N-terminal kinases and P38-MAPK, are the common intracellular pathway of transducing hypertrophic signs. All three MAPK subfamilies play an important role in development of myocardial hypertrophy.
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| 关 键 词： | 有丝分裂素激活蛋白激酶类 心肌 肥大 信号转导 |
| 文章编号： | 1000-4718(2005)07-1435-05 |
| 收稿时间： | 2003-12-22 |
| 修稿时间： | 2004-03-29 |
Role of mitogen-activated protein kinase in myocardial hypertrophy |
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| HUANG Zhao-yang,ZHU Jian-hua. Role of mitogen-activated protein kinase in myocardial hypertrophy[J]. Chinese Journal of Pathophysiology, 2005, 21(7): 1435-1439. DOI: 1000-4718 |
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| Authors: | HUANG Zhao-yang ZHU Jian-hua |
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| Affiliation: | DepartmentofCardiology,TheFirstAffiliatedHospital,CollegeofMedicine,ZhejiangUniversity,Hangzhou310003,China |
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| Abstract: | Myocardial hypertrophy is an independent risk factor for cardiac events. Mitogen-activated protein kinases (MAPK), including extracellular signal-regulated kinases, C-jun N-terminal kinases and P38-MAPK, are the common intracellular pathway of transducing hypertrophic signs. All three MAPK subfamilies play an important role in development of myocardial hypertrophy. |
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| Keywords: | Mitogen-activated protein kinases Myocardium Hypertrophy Signal transduction |
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