| 丹酚酸B稳定性研究进展 |
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| 引用本文： | 黄世超,瞿海斌. 丹酚酸B稳定性研究进展[J]. 中国现代应用药学, 2015, 32(5): 644-648 |
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| 作者姓名： | 黄世超 瞿海斌 |
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| 作者单位： | 浙江大学药物信息学研究所，杭州 310058,浙江大学药物信息学研究所，杭州 310058 |
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| 基金项目： | 国家自然科学基金项目(81273992) |
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| 摘 要： | 丹酚酸B是丹参中含量最高、活性较强的酚酸类成分，在水溶液中不稳定。文献报道丹酚酸B在弱酸性、低温和低离子浓度的体系中较为稳定。此外，一些抗氧化剂以及丹参酚酸成分的加入可以减缓丹酚酸B的降解。丹酚酸B的降解途径主要有酯键水解、呋喃环开环和脱羧反应等，降解后产生丹参素、紫草酸及其异构体、原儿茶醛和丹酚酸A、C、D、E、F等产物。本文从影响丹酚酸B降解的因素和丹酚酸B的降解途径两方面对丹参酚酸B稳定性的研究进展进行综述。
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| 关 键 词： | 丹酚酸B；稳定性；降解途径 |
| 收稿时间： | 2014-12-16 |
| 修稿时间： | 2015-03-26 |
Advances of Stability of Salvianolic Acid B |
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| HUANG Shichao and QU Haibin. Advances of Stability of Salvianolic Acid B[J]. The Chinese Journal of Modern Applied Pharmacy, 2015, 32(5): 644-648 |
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| Authors: | HUANG Shichao and QU Haibin |
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| Affiliation: | Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China and Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China |
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| Abstract: | Salvianolic acid B, an active compound, is the most abundant phenolic acid in Salvia miltiorrhiza Beg.. It is unstable in aqueous solution. According to the reports, salvianolic acid B is more stable in the solution with weak acid, low temperature and low ionic strength. And adding some antioxidants or salvianolic acid ingredients can reduce the degradation rate of salvianolic acid B. Hydrolysis of ester bonds, opening of furan rings and decarboxylation are the main degradation reactions of salvianolic acid B in aqueous solution, and these reactions can produce products, such as danshensu, lithospermic acid and its isomers, protocatechuic aldehyde, salvianolic acid A, C, D, E, F, etc. In this review, the advances of pathway and influence factors of salvianolic acid B degradation were summarized. |
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| Keywords: | salvianolic acid B stability degradation pathway |
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