重组(酵母)乙型肝炎疫苗免疫人群效果观察

目的　了解重组 (酵母 )乙型肝炎疫苗用于人群的免疫效果。方法　 1997- 2 0 0 2年 ,在对人群HBV感染指标 (HBsAg、抗 -HBs、抗 -HBc)测定的基础上 ,对易感人群进行重组 (酵母 )乙型肝炎疫苗的接种。2 0 0 3年 ,采用整群随机抽样的方法 ,从研究人群中抽取 5个研究人群 ,进行一般状况和HBV感染指标测定 ,以观察不同年龄、不同接种针次接种重组 (酵母 )乙型肝炎疫苗的免疫效果。结果　不同年龄的易感人群接种重组(酵母 )乙型肝炎疫苗HBsAg、抗 -HBc阳性率明显低于未接种组 ,抗 -HBs阳性率明显高于未接种组。 4 5岁以下人群免疫效果较好 ,抗 -HBs阳性率在 76.29%以上。免疫后 1- 5年 ,HBsAg阳性率维持在 1%以下 ,抗 -HBs阳性率保持在 77.66 %以上。不同接种针次效果不同 ,接种 1针次重组 (酵母 )乙型肝炎疫苗免疫效果较差 ;接种 2针或 3针免疫效果较好 ,抗 -HBs阳性率保持在 75.76 %以上。结论45岁以下易感人群接种重组 (酵母 )乙型肝炎疫苗能够获得良好的免疫效果.

Study on the Effects of Recombinant(Yeast)Hepatitis B Vaccine on the Inoculated Population

Objective To understand the immune effects of recombinant yeast hepatitis B vaccine (RYHBV) on human population. Methods: During 1997-2002, the inoculation of RYHBV was implemented among the vulnerable population on the basis of HBV infection index testing. In 2003, 5 groups of research population were obtained using cluster random sampling for the tests of common condition and HBV infection index to determine the immune effects of RYHBV based on different ages and inoculation times. Results: The HBsAg anti-HBc positive ratios of different age groups inoculated with RYHBV were remarkably lower than those of non-inoculated, and the anti-HBs ratio was apparently higher. The immune effects was better in population aged <45 years with anti-HBs positive ratio of more than 76.29%. Within 1-5 years after immunity, the HBsAg positive ratio remained below 1%, and the anti-HBs positive ratio above 77.66%. Different inoculation times resulted in different efficacy. One time inoculation had poor effect; and two or three times inoculation had better immune effects with anti-HBs positive ratio of over 75.76%. Conclusion Good immune effects could be acchieved among vulnerable population aged <45 years with the inoculation of recombinant hepatitis B vaccine.