Functional mapping of the effects of lesions of the habenular nuclei and their afferents in the rat |
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| Authors: | Nobutaka Motohashi ET MacKenzie Bernard Scatton |
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| Institution: | 1. Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Plaza Feijóo, s/n, E-33003, Oviedo, Spain;2. Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain;1. Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA;2. Cancer Biology Graduate Program, Stanford University School of Medicine, Stanford, CA, USA;3. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA;4. Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA;5. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA;1. Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland;2. Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland;1. Institute of Neuroscience, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA;2. Department of Psychiatry, New York University School of Medicine, 1 Park Avenue, New York, NY 10016, USA;3. Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA;4. The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA;1. Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA;1. Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA |
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| Abstract: | Through the use of the quantitative autoradiographic 2-14C]deoxyglucose technique, we have investigated the functional significance of the habenular nuclei by the measurement of local cerebral glucose utilization (LCGU) in discrete brain areas of conscious rats following 3 kinds of lesioning. Bilateral electrolytic lesions of the habenular nuclei decreased LCGU in a limited number of well-defined brain areas (the interpeduncular nucleus, median and dorsal raphe, mammillary body and dorsal tegmental nucleus) at 7 and 14 days after lesions. These changes were also observed 180 days following lesioning except that of the dorsal tegmental nucleus. At 14 days after bilateral ibotenic acid-induced lesions of the lateral habenula, LCGU was significantly decreased in the median and dorsal raphe, mammillary body and interpeduncular nucleus. In further studies, bilateral electrolytic lesions of the stria medullaris (which conveys the major afferents to the habenula) decreased glucose use in the interpeduncular nucleus less than that observed after bilateral electrolytic lesions of the habenular nuclei. A highly significant positive correlation was observed between LCGU and choline acetyltransferase activity in the interpeduncular nucleus after all types of lesion. These results further support the view that the medial and the lateral habenula exert a major influence upon functional activity in the interpeduncular nucleus and the mesencephalic raphe nuclei, respectively. |
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| Keywords: | 2-Deoxy-d-[14C]glucose technique Local cerebra glucose utilization Interpeduncular nucleus Median raphe Dorsal raphe Stria medullaris Habenular nucleus Choline acetyltransferase |
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