自体骨膜碎片血肿内植入修复骨缺损的实验研究与临床应用 |
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引用本文: | 张伯勋,陶笙.自体骨膜碎片血肿内植入修复骨缺损的实验研究与临床应用[J].中华外科杂志,1996,34(3):182-185. |
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作者姓名: | 张伯勋 陶笙 |
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作者单位: | 中国人民解放军总医院骨科 |
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摘 要: | 为探讨骨膜移植的成骨性能和不同血肿对其成骨的影响,作者在家兔双侧桡骨中段制成1.5cm长的骨缺损模型,并在缺损区内分别填以自体外周血块和骨髓血块。然后将自体骨膜碎片分别植入一侧血肿内,另一侧不植骨膜以作对照。通过X线、组织学、缺损区新生骨钙磷含量测定、骨组织形态测量和计算机图像分析等手段检测,结果证实自体骨膜碎片有成骨作用;自体骨髓血也有成骨潜能,但成骨能力弱于骨膜成骨;单纯外周血不能成骨;若以骨髓血为载体可使成骨作用提高。自体骨膜碎片血肿内植入临床应用12例,平均随访2年,临床效果满意。
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关 键 词: | 骨膜 骨缺损 修复 |
Repairingbonedefectwithautogenousperiostealpiecesincoagulum:experimentalstudyandclinicalap-plication |
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Abstract: | A1.5cm-longbonydefectwasestablishedinrabbitsoneeachonbothsides.Thedefect-edareawasfiledwithcoagulumofperipheralbloodorbonemarrowblood,thenautogenouspiecesoftheperiosteumwasputinthecoagulumononeside,whiletheothersidewasservedasthecontrolwith-outperiostealautograft.TheosteogeneticcapacityoftheperiosteumandtheinfluenceofdiferentbloodcoagulumwereevaluatedbymeansofX-rayfilm,histology,thecontentsofcalciumandphosphateinnewosteocytesinthedefectedarea,bonetissuemorphometry,andcomputer-assistedimageanalysis.Theautograftoftheperiosteumhadosteogeneticefect.Autologousbonemarowbloodhadpotentialosteogeneticcapacity,whichhowever,wasweakerthanthatoftheperiosteum.Peripheralbloodcoagu-lumdidnothaveanyosteogeneticefect.Wehavesuccessfulyusedtheperiosteum-bonemarowbloodcomplex(bonemarrowbloodasacarrier)in12patients. |
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Keywords: | PeriosteumBonedefectRepair |
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