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| 抗郁药P17致突变作用研究 | |
| 引用本文： | 谢智勇,黄世才,刘琳,涂英娥,田泽敏,周银平. 抗郁药P17致突变作用研究[J]. 江西中医学院学报, 2011, 23(2): 68-69 |
| 作者姓名： | 谢智勇 黄世才 刘琳 涂英娥 田泽敏 周银平 |
| 作者单位： | 1. 江西农业大学商学院,南昌,330045 2. 永丰县农业局,永丰,331500 3. 江西省职业病防治研究院,南昌,330006 |
| 摘 要： | 目的:评价抗郁药P17的致突变作用。方法:应用小鼠骨髓微核试验(GB 15193.5-2003)、Ames试验(GB 15193.4—2003)对抗郁药P17进行了致突变试验。结果:抗郁药P17三个试验剂量组微核率均在正常范围内,经SPSS中的Nonparametric tests检验与阴性对照组比较无显著性差异(P>0.05)。抗郁药P17在受试剂量63～1000μg/皿范围内,各剂量组各菌株与阴性对照组比较均未见回变菌落数明显增加。结论:本试验条件下抗郁药P17无致突变作用。 |
| 关 键 词： | 抗郁药P17 骨髓微核试验 Ames试验 |
A Study on the mutagenicity of Fluoxetine P17 |
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| XIE Zhi-yong,HUANG Shi-cai,LIU lin,TU Ying-e,TIAN Ze-min,ZHOU Yin-ping. A Study on the mutagenicity of Fluoxetine P17[J]. Journal of Jiangxi College of Traditional Chinese Medicine, 2011, 23(2): 68-69 | |
| Authors: | XIE Zhi-yong HUANG Shi-cai LIU lin TU Ying-e TIAN Ze-min ZHOU Yin-ping |
| Affiliation: | 1.Nanchang Business College of jxau,Nanchang 330045; 2.Yongfeng County Agricultual Bureau of Jiangxi Province,Yongfeng 331500; 3.Jiangxi Institute of Labor Hygiene and Occupational Medicine,Nanchang 330006 |
| Abstract: | Objectives：To evaluate the mutagenicity of Fluoxetine P17.Methods：The micronucleus test of in mice based on GB 15193.5-2003 and the Ames test based on GB 15193.4-2003 were applied.Results：The micronucleus rate form three-dosage-range groups of Fluoxetine P17 were all in the nomal range.The result by Nonporametric tests of SPSS showed there were no significant differences compared to the netagive control groups（P0.05）.At the dosoge range of 63~1000 μg Fluoxetine P17 per culture dish,the numbers of the revertent colonies from every group was not significantly higher than the negative control one.Conclusion：It is concluded that no mutagenicity effects of Fluoxetine P17 was detected under the condition of this experiment. |
| Keywords: | Fluoxetine P17 micronucleus testof bone marrow Ames test |
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