荧光分析法在药物分析中的应用研究进展

对常用的荧光分析方法和新型荧光分析在药物分析中的应用进行了评述。常用荧光分析方法有胶束增敏荧光分析法、反相胶束增敏荧光分析法、稀土荧光探针法和同步荧光分析法;新型的荧光分析法有荧光猝灭分析法、化学计量学方法、色谱-荧光联用技术和流动注射-荧光检测技术。认为,目前荧光分析法的主要发展趋势是:进一步寻找对药物荧光增强效果更好的胶束体系;详细研究荧光探针的作用机理,寻求专属性强、灵敏度更高、制备更简便的稀土荧光探针;联合多种检测技术,探索多组分复杂组成的样品的快速、准确检测的方法。

Research Progress of Fluorimetry in Pharmaceutical Analysis

Fluorescence analysis has been widely used in various pharmaceutical analysis of compound drug and body liquid for its high sensitive, selective, simple, reproducible and less consumed characteristic features. In this paper, the application of common and new type fluorescence analysis in pharmaceutical analysis was signified. The main fluorescent analysis methods include glue beam radio sensitizing fluorescence analysis, inverse glue beam radio sensitizing fluorescence analysis, rare earth fluorescence probe method and synchronous fluorescence analysis.New type of fluorescence analysis have fluorescence destroy analysis, chemo metrics methods, chromatography coupled techniques and fluorescence flow injection fluorimetry testing technology. Meanwhile, the main tendency was prospected.