| 复方穿心莲掩味混悬颗粒的制备工艺 |
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| 引用本文： | 孙莎莎,张国松,刘微,刘晓燕,张尧,饶晓勇,罗晓健.复方穿心莲掩味混悬颗粒的制备工艺[J].中国实验方剂学杂志,2011,17(12):12-17. |
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| 作者姓名： | 孙莎莎 张国松 刘微 刘晓燕 张尧 饶晓勇 罗晓健 |
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| 作者单位： | 孙莎莎,刘微,刘晓燕,SUN Sha-sha,LIU Wei,LIU Xiao-yan(江西中医学院,南昌,330004);张国松,张尧,饶晓勇,ZHANG Guo-song,ZHANG Yao,RAO Xiao-yong(中药固体制剂制造技术国家工程研究中心,南昌,330006);罗晓健,LUO Xiao-jian(江西中医学院,南昌330004;中药固体制剂制造技术国家工程研究中心,南昌330006) |
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| 摘 要： | 目的:改善复方穿心莲颗粒的口感,研究适合儿童服用的掩味混悬颗粒制备工艺。方法:采用流化床底喷工艺制备掩味颗粒,以脱水穿心莲内酯溶出度检测与口感打分、沉降容积为指标,评价掩味混悬颗粒的掩味效果。结果:尤特奇E100作包衣材料,对复方穿心莲颗粒有很好的掩味效果,制备的掩味混悬颗粒在水中分散均匀,口感良好。结论:颗粒包衣工艺掩味效果佳,制备的掩味混悬颗粒适合儿童患者服用。
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| 关 键 词： | 穿心莲 掩味 颗粒包衣 混悬颗粒 |
| 收稿时间： | 2011/1/27 0:00:00 |
| 修稿时间： | 3/3/2011 12:52:09 AM |
Preparation Technology of AndrographisPaniculta Compound Taste Masking Suspension Particle |
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| SUN Sha-sh,ZHANG Guo-song,LIU Wei,LIU Xiao-yan,ZHANG Yao,RAO Xiao-yong and LUO Xiao-jian.Preparation Technology of AndrographisPaniculta Compound Taste Masking Suspension Particle[J].China Journal of Experimental Traditional Medical Formulae,2011,17(12):12-17. |
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| Authors: | SUN Sha-sh ZHANG Guo-song LIU Wei LIU Xiao-yan ZHANG Yao RAO Xiao-yong and LUO Xiao-jian |
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| Institution: | Jiangxi University of Traditional Chinese Medicin, Nanchang 330004,China;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006,China;Jiangxi University of Traditional Chinese Medicin, Nanchang 330004,China;Jiangxi University of Traditional Chinese Medicin, Nanchang 330004,China;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006,China;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006,China;Jiangxi University of Traditional Chinese Medicin, Nanchang 330004,China; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006,China |
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| Abstract: | Objective: This research aims to improve the taste of andrographitis compound particle, and to research the preparation technology of taste masking suspension particle which suits children. Method: Particle coating was applied to prepare taste masking particle, through building the relation of concentration with mouth taste and dissolution of dehydroandrographolide of two inspection methods to evaluate the effect of taste masking. On the basis of taste masking, the suspension of taste masking particle was prepared that can be taken by children suitably. Result: Eudragit E100 coating is good for tasting masking. The suspension particles made with the method of coating dispersed in water evenly and tasted good. Conclusion: The coating particle has good effect on taste masking. And the preparation of taste masking suspension particle is suitable for children patients to take. |
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| Keywords: | andrographitis taste masking coating particle suspension particle |
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