川芎血清药物化学的初步研究

目的:对川芎进行血清药物化学研究。方法:建立川芎提取液及川芎提取液灌胃后大鼠血清的HPLC指纹图谱,分析川芎提取液给药后所得血清样品,鉴定川芎提取液灌胃后大鼠血中移行成分。结果:川芎提取液灌胃后从血中发现了7个入血成分,其中4个为代谢产物;3个为原型成分。结论:川芎入血成分主要为川芎嗪和阿魏酸,其血清药物化学表征可以为阐明川芎药理作用及其质量控制提供依据。

Preliminary Study on Serum Pharmacochemistry of Chuanxiong Extract

Objective: To have a serum pharmacochemistry study on chuanxiong extract. Method: HPLC fingerprints of chuanxiong extract and serum of rats after taking the extract were established with serum pharmacochemistry method. The serum samples taken after taking chuanxiong extract were compared,the constituents absorbed into the serum after taking chuanxiong extract was determined. Result: Seven constituents migrating to the blood were detected, of which 4 were metabolites, 3 were prototype constituents. Conclusion: After taking chuanxiong extract,the constituents absorbed into blood were ligustazine and ferulic acid whose serum pharmacochemistry signs could provide evidence for the pharmacological action and quality control of chuanxiong.