| 桃仁对单侧输尿管梗阻大鼠肾小管上皮细胞转分化的影响 |
| |
| 引用本文： | 李小波,边壮,兰萍,刘颖. 桃仁对单侧输尿管梗阻大鼠肾小管上皮细胞转分化的影响[J]. 中国实验方剂学杂志, 2011, 17(13): 189-191 |
| |
| 作者姓名： | 李小波 边壮 兰萍 刘颖 |
| |
| 作者单位： | 1. 遵义医学院珠海校区临床技能中心诊断学实验室,广东珠海,519000
2. 中山大学附属第五医院,广东珠海,519000 |
| |
| 摘 要： | 目的:探讨桃仁对单侧输尿管结扎诱导的肾间质纤维化实验大鼠肾小管上皮细胞转分化的影响。方法:采用单侧输尿管结扎(UUO)肾间质纤维化模型。将大鼠随机分为4组,正常组、模型组ig给2 mL自来水,蒙诺组ig予10 mg·kg-1和桃仁组ig予6 g·kg-1释成冲剂2 mL,每日1次。术后14 d处死大鼠,观察肾组织病理改变,并应用免疫组织化学方法检测肾组织上皮细胞钙黏蛋白(E-cadherin),α-平滑肌激动蛋白(α-SMA)和纤维连接蛋白(FN)的表达。结果:与正常组相比,模型组肾小管上皮细胞E-cadherin有较弱表达,肾间质α-SMA和FN有较强的表达(P<0.05);与模型组相比,桃仁组纤维化程度减轻,且α-SMA和FN的阳性表达较模型组显著减弱,E-cadherin表达较强,有统计学差异(P<0.05),桃仁组与蒙诺组比无统计学差异少。结论:桃仁可能通过增强E-cadherin、减弱α-SMA和FN的表达改善肾小管上皮细胞转分化,而减缓肾间质纤维化病程进展。
|
| 关 键 词： | 桃仁 肾小管上皮细胞转分化 上皮细胞钙黏蛋白 |
| 收稿时间： | 2011-01-09 |
Influnence of Persicae Semen on Epithelial-mesenchymal Transdifferentiation of Renal Tubular in Rats with Unilateral Ureteral Obstruction |
| |
| LI Xiao-bo,BIAN Zhuang,LAN Ping and LIU Ying. Influnence of Persicae Semen on Epithelial-mesenchymal Transdifferentiation of Renal Tubular in Rats with Unilateral Ureteral Obstruction[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(13): 189-191 |
| |
| Authors: | LI Xiao-bo BIAN Zhuang LAN Ping LIU Ying |
| |
| Affiliation: | Technical Center, Zhuhai Campus of Zunyi Medical College, Zhuhai 519000, China;The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China;The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China;Technical Center, Zhuhai Campus of Zunyi Medical College, Zhuhai 519000, China |
| |
| Abstract: | |
| |
| Keywords: | Persicae Semen epithelial-mesenchymal transdifferentiation of renal tubular E-cadherin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
|
点击此处可从《中国实验方剂学杂志》下载全文 |
|
