同步热放化疗对宫颈癌组织VEGF蛋白表达的影响

目的：研究同步热放化疗治疗宫颈癌的疗效，分析治疗前和治疗中对宫颈癌组织VEGF蛋白表达的影响。方法：将40例宫颈癌1IIb期分为同步热放化疗组（H＋CRT组）和同步放化疗组（CRT组），观察比较局部肿瘤消退情况和1，2，3年累积生存率；采用免疫组化法检测两组治疗前、中宫颈肿瘤组织中VEGF蛋白表达。结果：在完成体外照射27Gy时H＋CRT组局部肿瘤完全消退率高于CRT组（P〈0.05），但两组患者的1，2，3年累积生存率比较，差异无统计学意义（P〉0.05）；两组治疗中VEGF蛋白表达强度均较治疗前减弱，差异有统计学意义（P〈0.05）；治疗中H＋CRT组VEGF蛋白表达强度较CRT组减弱，差异有统计学意义（P〈0．05）。结论：同步热放化疗能有效降低肿瘤VEGF的表达强度，抑制肿瘤增殖，促进肿瘤消退。热疗与同步放化疗具有协同增强作用。

EFFECT OF HYPERTHERMIA COMBINED WITH SYNCHRONOUS RADIOTHERAPY AND CHEMOTHERAPY ON THE EXPRESSION OF VEGF PROTEIN IN CERVICAL CANCER

Objective： To study the efficacy of hyperthermia combined with synchronous radiotherapy and chemotherapy in treatment of patient with stage Ⅲ b cervical cancer, and to analyse expression of VEGF protein of cervical cancer pre-treatment and the course of treatment. Methods：Fourty patients were divided randomly into two groups： hyperthermia combined with synchronous radiotherapy and chemotherapy （H＋ CRT） group and synchronous radiotherapy and chemotherapy （CRT） group. To compare the local tumor regression and the 1, 2, 3-year cumulative survival rate between two groups. The protein expression of VEGF in cervical cancer biopsy samples was detected by immunohistochemistry pre-treatment and the course of treatment. Results：The tumor regression rates in the H＋CRT group were higher than those in CRT group when irradiated 27Gy（ P 〈0. 05）. There was no significant difference in the cumulative survival rate of 1,2,3-year comparison between two groups（ P 〉0. 05）. VEGF protein expression rates of two groups in the course of treatment were weakened significantly than pre-treatment（ P 〈0. 05）. In the course of treatment, VEGF protein expression rates in H＋CRT group were weakened significantly than those in the CRT group （ P 〈0.05）. Conclusion： Hyperthermia combined with synchronous radiotherapy and chemotherapy could weaken the VEGF protein expressive intensity, and could improve local tumor regression rates in cervical cancer.