| 五味子复方对模拟航渡及高强度运动大鼠下丘脑-垂体-肾上腺轴功能和代谢的影响 |
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| 引用本文： | 黄慧,孙玲君,顾萍,王坚. 五味子复方对模拟航渡及高强度运动大鼠下丘脑-垂体-肾上腺轴功能和代谢的影响[J]. 中国实验方剂学杂志, 2011, 17(12): 136-140 |
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| 作者姓名： | 黄慧 孙玲君 顾萍 王坚 |
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| 作者单位： | 南京大学医学院临床学院南京军区南京总医院内分泌科,南京,210002 |
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| 基金项目： | 南京军区"十一五"面上课题 |
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| 摘 要： | 目的:探讨五味子复方对模拟航渡及大强度运动大鼠下丘脑-垂体-肾上腺轴功能和代谢的影响。方法:选取31只大鼠,随机分成安静组(A组),应激组(B组)和五味子复方组(C组),大鼠给予五味子复方煎液10 mL.kg-1,2次/d ig,剂量为20 g·kg-1,共1周,B组和C组给予模拟渡航及高强度运动,比较3组大鼠血糖(blood glucose)、甘油三酯(triglyceride,TG)、胆固醇(cholesterol,CHO)及皮质醇(corticosterone,CORT)水平,并观察3组大鼠垂体促肾上腺皮质激素(adrenocorticotropichormone,ACTH)、神经肽Y(neuropeptide Y,NPY)阳性细胞数量和肾上腺皮质的超微结构。结果:①与A组相比,B组血糖水平显著增高(9.41±2.56)mmol.L-1,P<0.01,TG和CHO水平显著降低,TG(0.42±0.16)mmol.L-1,P<0.01;CHO(1.69±0.23)mmol.L-1,P<0.05;C组与B组相比,其血糖水平降低(6.45±2.25)mmol.L-1,P<0.05,TG水平升高(0.63±0.22)mmol.L-1,P<0.05,CHO无明显差异(1.83±0.19)mmol.L-1。②垂体ACTH和NPY阳性细胞免疫组化结果:C组ACTH阳性细胞和NPY阳性细胞数量较应激组增加,但两组都少于A组。③肾上腺电镜结果:与A组相比,B组肾上腺皮质细胞中分泌颗粒数目明显减少;C组肾上腺皮质细胞内分泌颗粒数目较B组明显增多。结论:五味子复方能降低应激大鼠血糖水平,维持物质代谢平衡,提高大鼠抗应激能力,保护垂体和肾上腺组织的结构功能。
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| 关 键 词： | 五味子复方 模拟航渡 高强度运动 下丘脑-垂体-肾上腺轴 皮质醇 |
| 收稿时间： | 2010-12-02 |
Effects of Schisandra Chinensis Fructus Compound on Function of Hypothala-Muspituitary-Adrenal Axis and Metabolism in Rats Underwent ExperimentalNavigation and Strenuous Exercise |
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| HUANG Hui,SUN Ling-jun,GU Ping and WANG Jian. Effects of Schisandra Chinensis Fructus Compound on Function of Hypothala-Muspituitary-Adrenal Axis and Metabolism in Rats Underwent ExperimentalNavigation and Strenuous Exercise[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(12): 136-140 |
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| Authors: | HUANG Hui SUN Ling-jun GU Ping WANG Jian |
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| Affiliation: | Department of Endocrinology, School of Clinical Medicine, Nanjing University Medical College Nanjing General Hospital of Nanjing Military Region, Nanjing 210002, China;Department of Endocrinology, School of Clinical Medicine, Nanjing University Medical College Nanjing General Hospital of Nanjing Military Region, Nanjing 210002, China;Department of Endocrinology, School of Clinical Medicine, Nanjing University Medical College Nanjing General Hospital of Nanjing Military Region, Nanjing 210002, China;Department of Endocrinology, School of Clinical Medicine, Nanjing University Medical College Nanjing General Hospital of Nanjing Military Region, Nanjing 210002, China |
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| Abstract: | |
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| Keywords: | Schisandra Chinensis Fructus compound simulated navigation and combat strenuous exercise hypothalamus-pituitary-adrenal axis corticosterone |
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