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| 基于以抗肿瘤为主要活性的黄药子毒性研究进展及对策 | |
| 引用本文： | 王君明,雷军锋,季莉莉,刘海,王峥涛,崔瑛.基于以抗肿瘤为主要活性的黄药子毒性研究进展及对策[J].中国实验方剂学杂志,2011,17(12):256-260. |
| 作者姓名： | 王君明 雷军锋 季莉莉 刘海 王峥涛 崔瑛 |
| 作者单位： | 1. 河南中医学院药学院,郑州450008;上海中医药大学中药研究所中药标准化教育部重点实验室暨中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海201210;上海中药标准化研究中心,上海201210 2. 河南省计量科学研究院,郑州,450008 3. 上海中医药大学中药研究所中药标准化教育部重点实验室暨中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海201210;上海中药标准化研究中心,上海201210 4. 上海中医药大学中药研究所中药标准化教育部重点实验室暨中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海,201210 5. 河南中医学院药学院,郑州,450008 |
| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划(973计划)项目，河南中医学院博士科研基金 |
| 摘 要： | 笔者查阅国内外相关研究资料并进行汇总、分析,介绍了以抗肿瘤为主要活性的黄药子的毒性研究进展及对策。黄药子可诱导毒性(尤其是肝毒性),但毒性成分、毒性成分与抗肿瘤活性成分的关系、毒性/肝毒性机制均尚不清楚。建议开展黄药子的抗肿瘤作用机制、毒性成分与抗肿瘤活性成分的相关性、毒性/肝毒性的作用机制以及配伍减毒增效的研究,最终为其临床安全有效用药提供有意义的参考,并为其他有毒中药的研究提供思路借鉴。 |
| 关 键 词： | 黄药子 毒性 抗肿瘤活性 对策 |
| 收稿时间： | 2011/1/15 0:00:00 |
Research Progress and Strategy in Toxicity of Dioscorea bulbiferaRhizome with Main Bioactivity of Antitumor Action |
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| WANG Jun-ming,LEI Jun-feng,JI Li-li,LIU Hai,WANG Zheng-tao and CUI Ying.Research Progress and Strategy in Toxicity of Dioscorea bulbiferaRhizome with Main Bioactivity of Antitumor Action[J].China Journal of Experimental Traditional Medical Formulae,2011,17(12):256-260. | |
| Authors: | WANG Jun-ming LEI Jun-feng JI Li-li LIU Hai WANG Zheng-tao and CUI Ying |
| Institution: | School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China; MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai 201210, China;Henan Institute of Metrology, Zhengzhou 450008, China;MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai 201210, China;MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China;MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai 201210, China;School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China |
| Abstract: | The authors introduced the research progress and strategy in the toxicity of Dioscoreae bulbifera rhizome with the main bioactivity of antitumor action by looking through the related information and references,further analyzing and reviewing them.Previous studies showed that D.bulbifera rhizome could induce toxicity,especially for hepatotoxicity.However,up to now,the toxic chemical components are still not clear.The relationship between the antitumor active and toxic components and the mechanisms are not known,too.Therefore,we should carry out further studies on mechanism-based antitumor action and toxicity of the D.bulbifera rhizome,to determine the safe and effective therapeutic window,and even to explore detoxification and enhancement actions by combination with other medicines so as to ensure its safety and validity in clinic application.Besides,the present paper may also provide the research guidance in thoughts for other toxic Chinese medicine. |
| Keywords: | Dioscoreae bulbifera toxicity antitumor action strategy |
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