| 卡托普利和氯沙坦对血管性痴呆模型大鼠氧自由基及一氧化氮的影响 |
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| 引用本文： | 黄新武,李国春,李华,张红,章卓,秦大莲.卡托普利和氯沙坦对血管性痴呆模型大鼠氧自由基及一氧化氮的影响[J].中国老年学杂志,2011,31(13). |
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| 作者姓名： | 黄新武 李国春 李华 张红 章卓 秦大莲 |
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| 作者单位： | 1. 泸州医学院药学院药理学教研室,四川,泸州,646000
2. 泸州医学院附属中医院药剂科 |
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| 基金项目： | 四川省卫生厅科研资助项目 |
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| 摘 要： | 目的 观察卡托普利和氯沙坦对血管性痴呆(VD)模型大鼠超氧化物歧化酶(SOD),丙二醛(MDA),一氧化氮(NO)及一氧化氮合酶(NOS)的影响,分析卡托普利和氯沙坦抗脑缺血损伤的作用机制.方法 采用不同时间点分别结扎左、右颈总动脉建立大鼠血管性痴呆模型,用卡托普利和氯沙坦灌胃给药4 w观察学习记忆能力后,测定脑组织SOD活性、MDA、NO含量及NOS活力的变化.结果 卡托普利组和氯沙坦组均可拮抗脑缺血引起的脑组织SOD活性的下降及MDA含量的升高,能明显抑制脑组织NOS活性及NO的含量.结论 卡托普利及氯沙坦均可通过增加氧自由基的清除,影响NOS的活性及NO的含量改善VD模型大鼠学习记忆能力.
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| 关 键 词： | 卡托普利 氯沙坦 血管性痴呆 氧自由基 一氧化氮 一氧化氮合酶 |
Effect of captopril and losartan on free radical and nitric oxide change after cerebral ischemia in rats |
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| HUANG Xin-Wu,LI Guo-Chun,LI Hua,et al..Effect of captopril and losartan on free radical and nitric oxide change after cerebral ischemia in rats[J].Chinese Journal of Gerontology,2011,31(13). |
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| Authors: | HUANG Xin-Wu LI Guo-Chun LI Hua |
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| Institution: | HUANG Xin-Wu,LI Guo-Chun,LI Hua,et al.Department of Pharmacology,Luzhou Medical College,Luzhou 646000,Sichuan,China |
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| Abstract: | Objective To observe the effect of captopril and losartan on free radical and nitric oxide(NO) and nitric oxide synthase(NOS) change after cerebral ischemia in rats and analyze the mechanisms of captopril and losartan anti-cerebral ischemia action.Methods SD rats were randomly divided into sham-operated,untreated,captopril-treated and losartan-treated groups.The animal models were produced by permanent occlusion in two times operation at 3 days interval of bilateral common carotid arteries of rats.Captopril... |
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| Keywords: | Captopril Losartan Vascular dementia Free radical Nitric oxide(NO) Nitric oxide synthase(NOS) |
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