The prognostic value of multivoxel magnetic resonance spectroscopy determined metabolite levels in white and grey matter brain tissue for adverse outcome in term newborns following perinatal asphyxia |
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| Authors: | Pieter Jan van Doormaal Linda C Meiners Hendrik J ter Horst Christa N van der Veere Paul E Sijens |
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| Institution: | (1) Department of Pediatrics, Division of Neonatology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands;(2) Department of Radiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands;(3) Present address: Department of Radiology, Meander Medical Center Amersfoort, PO Box 1502, 3800 BM Amersfoort, the Netherlands; |
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| Abstract: | Objective Magnetic resonance spectroscopy can identify brain metabolic changes in perinatal asphyxia by providing ratios of metabolites,
such as choline (Cho), creatine (Cr), N-acetyl aspartate (NAA) and lactate (Lact) Cho/Cr, Lact/NAA, etc.]. The purpose of
this study was to quantify the separate white and grey matter metabolites in a slab cranial to the ventricles and relate these
to the outcome. |
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