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The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis |
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| Authors: | Xu?Cai,Ming?Yang author-information" > author-information__contact u-icon-before" > mailto:yangm@mail.buct.edu.cn" title=" yangm@mail.buct.edu.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Orthopedics, Division of Surgery, Chinese PLA General Hospital, Beijing, China;(2) College of Life Science and Technology, Beijing University of Chemical Technology, P. O. Box 53, Beijing, 100029, China; |
| Abstract: | PurposeThe P53–MDM2 pathway plays a central role in sarcoma pathogenesis. Functional P53 Arg72Pro and MDM2 T309G single-nucleotide polymorphisms (SNP) are considered to have significant effects on risk of sarcomas. |
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