(1) Department of Orthopedics, Division of Surgery, Chinese PLA General Hospital, Beijing, China;(2) College of Life Science and Technology, Beijing University of Chemical Technology, P. O. Box 53, Beijing, 100029, China;
Abstract:
Purpose
The P53–MDM2 pathway plays a central role in sarcoma pathogenesis. Functional P53 Arg72Pro and MDM2 T309G single-nucleotide polymorphisms (SNP) are considered to have significant effects on risk of sarcomas.