Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells |
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| Authors: | Yun-Hee Rhee Soo-Jin Jeong Hyo-Jeong Lee Hyo-Jung Lee Wonil Koh Ji Hoon Jung Sun-Hee Kim Kim Sung-Hoon |
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| Affiliation: | (1) Clinical Trial Institute, Dankook University, Chenan, 330-714, South Korea;(2) College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, South Korea |
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| Abstract: | Background Ergosterol peroxide (EP) derived from edible mushroom has been shown to exert anti-tumor activity in several cancer cells. In the present study, anti-angiogenic activity of EP was investigated with the underlying molecular mechanisms in human multiple myeloma U266 cells. |
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