| Abstract: | Interaction between factor XII and surfaces having different physicochemical properties, and the effect of surfactants, urea, EDTA, and an increased ionic strength on its desorption were studied. The results showed that factor XII can be activated by interaction of the blood plasma with surfaces having negative and positive charges, and its desorption was induced by all agents to a different degree. The most important condition for activation of factor XII was shown to be electrostatic interaction with a surface having the highest charge density. The formation of hydrogen bonds of protein protons with the frequently distributed oxygen atoms on the surface of silica provides the most favorable conditions for manifestation of the enzyme activity. |
