| 静注用免疫球蛋白对血管内皮细胞的体外作用 |
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| 引用本文： | 徐晨. 静注用免疫球蛋白对血管内皮细胞的体外作用[J]. 现代免疫学, 1998, 18(4): 223-227 |
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| 作者姓名： | 徐晨 |
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| 作者单位： | 上海第二医科大学组织胚胎学教研室 上海200025 |
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| 基金项目： | 法国外交部基金(3Q4/044)和法国Rhōne-Poulenc Rorer基金(97043)资助 |
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| 摘 要： | 本文观察到静脉注射用免疫球蛋白(IVIg)体外抑制脐静脉内皮细胞(HUVEC)的增殖.其中IVIg分子的Fc和F(ab’)_ 2片段都能发挥作用,并且抑制是可逆的.IVIg对于HUVEC几乎没有细胞毒作用.IVIg对VCAM-1、ICAM-l mRNA的表达没有明显影响,但是IVIg对于由TNFa或IL-lβ增强的VCAM-1、ICAM-1表达呈明显的下调作用.
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| 关 键 词： | IVlg 脐静脉内皮细胞 细胞因子 粘附分子 炎症 |
Effect of Intravenous Immunoglobulin (IVIg ) on Endothelial Cells in Culture |
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| Xu Chen. Effect of Intravenous Immunoglobulin (IVIg ) on Endothelial Cells in Culture[J]. Current Immunology, 1998, 18(4): 223-227 |
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| Authors: | Xu Chen |
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| Abstract: | The effect of IVIg on the in vitro activation of human endothelial cells, as assessed by cell proliferation and RT-PCR-detected expression of mRNA coding for VCAM-1 and ICAM-1 adhesion molecules , has been investigated in this study. The results showed that IVIg inhibited the proliferation of endothelial cells. This effect was dependent on both Fc and F (ab' )2 fragments of the immunoglobulin molecule and fully reversible. IVIg had little cytotoxic effect as observed by cell viability and had no effect on basal levels of VCAM-1 and ICAM-1 mRNA, but fully down-regulated the expression of mRNA coding for these two adhesion molecules induced by TNF-a or IL-1β |
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| Keywords: | IVIg HUVEC cytokines adhesion molecules inflammation |
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