| 癌症患者红细胞CR_1基因多态性研究 |
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| 引用本文： | 郭峰,邬伟秀.癌症患者红细胞CR_1基因多态性研究[J].现代免疫学,1998,18(2):88-89. |
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| 作者姓名： | 郭峰 邬伟秀 |
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| 作者单位： | 第二军医大学长海医院免疫室!上海200433(郭峰，张俊洁，赵书平)，上海市第一人民医院血液科!上海200085(邬伟秀，杨新潮) |
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| 基金项目： | 国家自然科学基金资助项目(批准号39670754) |
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| 摘 要： | 为了探讨女性癌症患者红细胞补体受体Ⅰ型(ECR_1)密度相关基因多态性的变化,采用血细胞DNA PCR和HindⅢ酶切技术对44例癌症女性患者红细胞CR_1密度相关基因多态性分布进行了测定,发现癌症女性患者红细胞CR_1密度相关基因点突变率高达54.5％,尤其是40岁以下的女性癌症患者红细胞CR_1密度相关基因点突变率(72.73％)比40岁以下女性正常人(20.80％)明显增高。表明年轻女性癌症患者癌变易感性与红细胞CR_1密度相关基因缺陷有一定的关系。
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| 关 键 词： | 癌症 女性 红细胞补体受体Ⅰ型(ECR_1) 基因 |
Studies on the CR1 Density-Associated Genomic Polymorphism on Erythrocytes in Women Patients with Cancers |
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| Guo Feng,Zhang Junjie,Zhao Shaping,et al..Studies on the CR1 Density-Associated Genomic Polymorphism on Erythrocytes in Women Patients with Cancers[J].Current Immunology,1998,18(2):88-89. |
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| Authors: | Guo Feng Zhang Junjie Zhao Shaping |
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| Abstract: | To study the changes of CR1 density-associated genomic polymorphism on erythro-cytes, polymerase chain reaction (PCR) and Hind Ⅲ restriction enzyme digestion technique were used in 44 cases of women patients with cancers. It was found that the incidence of point mutation on the CR1 density-associated polymorphism in women patients with cancers was rather high (54. 5%), especially those patients under 40 years old (72. 73%). and it was significantly higher than that of the normal women(20. 8%). These results suggest that the erythrocyte CR1(ECR1) gene in women might be related to the susceptibility to carcinogenesis in young women. |
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| Keywords: | cancer women erythrocyte CR1(CD35) gene |
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