氯苯丙氨酸对褪黑素免疫调节作用的影响

本文研究了5-羟色胺（5-HT）合成抑制剂对氯苯丙氨酸（PCPA）对褪黑素（MT）免疫调节作用的影响。结果表明,MT20μg/kg可以显著升高小鼠外周血淋巴细胞百分率（Lym％）、T-淋巴细胞百分率（T-Lym％）与血清溶血素生成水平（半数溶血值,HC_(50)值）,PCPA 10～40mg/kg本身对小鼠Lym％、T-Lym％及HC_(50)基本无影响,但可完全抑制MT升高Lym％、T-Lym％与HC_(50)值的作用,提示MT的免疫调节作用机制之一可能与5-HT介导有关。

Effects of PCPA on the Immune Regulation Actions of Melatonin in Mice

Effects of PCPA, an inhibitor of 5-HT synthesis, on the immune regulations ofmelatonin (MT) in mice were studied. The results showed that MT in concentration of 20/ug/kg significantly enhanced lymphocyte percentage (Lym%), T-lymphocyte percentage (T-Lym%) and serum hemolysis formation (HC5() value) in peripheral blood of mice, but had no direct influence on Lym% , T-Lym% and HC50 value and almost completely suppressed the immune enhancement of MT. It is suggested that one of mechanisms of MT immune enhancement may be through the intermediation of 5-HT.