| SLE患者IgG类抗-Sm/抗-U_1RNP自身抗体进入存活Hep-2细胞内的观察 |
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| 引用本文： | 沈燕 仲人前. SLE患者IgG类抗-Sm/抗-U_1RNP自身抗体进入存活Hep-2细胞内的观察[J]. 现代免疫学, 1998, 18(4): 210-211 |
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| 作者姓名： | 沈燕 仲人前 |
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| 作者单位： | 上海长征医院全军临床免疫中心 上海200003(沈燕，仲人前)，上海长征医院全军临床免疫中心 上海200003(孔宪涛) |
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| 摘 要： | 本文采用生物素-亲合素-碱性磷酸酶法(ABC-AKP)检测10例正常人血清和7例系统性红斑狼疮(SLE)病人血清中IgG类抗-Sm/抗-U_1RNP抗体对Hep-2细胞的进入作用.结果表明:自身抗体能够进入存活的Hep-2细胞,患者组阳性者4例(57.14%),对照组皆为阴性(P<0.05).讨论了自身抗体进入活的靶细胞在自身免疫性疾病发病中的意义.
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| 关 键 词： | ABC-AKP法 自身抗体 自身免疫 |
Observation on the Penetration of IgG Autoantibodies Against Sm or U_1RNP of SLE Patients into Hep-2 Cells |
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| Shen Yan,Zhong Renqian,Kong Xiantao. Observation on the Penetration of IgG Autoantibodies Against Sm or U_1RNP of SLE Patients into Hep-2 Cells[J]. Current Immunology, 1998, 18(4): 210-211 |
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| Authors: | Shen Yan Zhong Renqian Kong Xiantao |
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| Abstract: | By means of avidin-biotin-alkaline phosphatase technique, we have demonstrated the penetration of IgG autoantibodies against Sm or U1RNP in sera of 10 normal donors and 7 patients with systemic lupus erythematosus into the viable Hep-2 cells. There were 4 cases with positive results in the patient group (57. 14%), and all in the control group showed negative results. The significance of these findings in the pathogenesis of autoimmune diseases was discussed. |
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| Keywords: | ABC-AKP technique autoantibody autoimmunity |
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