| 哮喘患儿血浆NO、IL和TNF的变化及意义 |
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| 引用本文： | 蒋东波 李华强. 哮喘患儿血浆NO、IL和TNF的变化及意义[J]. 现代免疫学, 1998, 18(5): 292-294 |
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| 作者姓名： | 蒋东波 李华强 |
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| 作者单位： | 第三军医大学附属大坪医院野战外科研究所 重庆400042(蒋东波，李华强，史源，潘捷，沈际皋，姚忠凯)，第三军医大学附属大坪医院野战外科研究所 重庆400042(刘萍) |
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| 摘 要： | 采用镉还原柱层析和比色法测定了42例哮喘患儿外周血亚硝酸/硝酸根离子(NO_2~-/NO_3~-)水平,另用生物学活性法测定了白细胞介素2、4、6(IL-2、4、6)及肿瘤坏死因子(TNF)水平.结果:小儿哮喘发作期外周血IL-2、4、6,TNF及NO水平均明显高于正常儿童(P分别<0.05,<0.01);在缓解期IL-2,6,NO水平恢复正常水平(P均>0.05),而IL-4,TNF水平虽较发作期有明显降低,但仍高于正常儿童(P均<0.01).提示:NO,IL-2、4、6及TNF参与了哮喘的病理生理过程,是哮喘气道高反应性及变应性炎症的重要介质,在哮喘的免疫发病机制中占有重要地位.
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| 关 键 词： | 哮喘 儿童 白细胞介素2、4、6 肿瘤坏死因子 |
The Alterations of Plasma Nitric Oxide, Interleukin-2, 4, 6 and Tumor Necrosis Factor Levels in Asthmatic Children and Their Significances |
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| Jiang Dongbo,Li huaqing,Shi Yuan,et al. The Alterations of Plasma Nitric Oxide, Interleukin-2, 4, 6 and Tumor Necrosis Factor Levels in Asthmatic Children and Their Significances[J]. Current Immunology, 1998, 18(5): 292-294 |
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| Authors: | Jiang Dongbo Li huaqing Shi Yuan et al |
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| Abstract: | The plasma levels of NO, IL-2, 4, 6 and TNF were determined in 42 cases of asthmatic children and 20 matched normal children. It was found that all the asthmatic children in acute attacks had increased plasma levels of NO2?NO3? IL-2, 4, 6 and TNF in comparison with the normal controls. During the remission stage, plasma levels of IL-2, 6 and NO returned to normal. Although the levels of IL-4 and TNF were still higher than those during acute attacks, yet they showed a remarkable reduction, these result suggest that NO, IL-2, 4, 6 and TNF participate the pathophysiological processes of asthma; and being the mediators in airway hyperreactivity, they play an important role in the immunological mechanisms of asthma. |
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| Keywords: | asthma nitric oxide interleukin-2 4 6 tumor necrosis factor |
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