针刺预处理对脑缺血/再灌注损伤的保护作用

针刺预处理的脑保护可能机制如下:减轻脑水肿和微血管损伤,增加脑血流量,影响缺血脑组织在病理形态学及超微结构改变,有利于维持细胞内外离子的稳态,对抗自由基损伤及脂质过氧化反应.并影响细胞因子、神经递质及脑细胞信号转导、凋亡调节基因等;针刺预处理对脑缺血/再灌注的保护效果表现为其穴位、刺激频率和刺激持续时间上的特异性.

Acupuncture preconditioning-induced brain protection against cerebral ischemia/reperfusion injury

The mechanisms of acupuncture preeonditioning on brain protection may be to reduce cerebral hydrocephalus and capillary damage,to increase brain blood flow,and to improve the uhrastructural change of ischemic brain tissues in pathology and morphology.Acupuncture preconditioning may also keep the extraceUular and intracellular ion balance,attenuatefree radical damage and lipid peroxidization,and regulate cytokine and neurotransmitter release,cell signal conduction,apopto-sis gene expression,etc.Acupuncture preconditioning-induced cerebral protection presents specificity in acupuncture point,sti-mulation frequency and duration.