| 北方汉族Grave病与HLA相关性研究 |
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| 引用本文： | 鲁梅花,邵文硕. 北方汉族Grave病与HLA相关性研究[J]. 首都医科大学学报, 2000, 21(2): 122-124 |
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| 作者姓名： | 鲁梅花 邵文硕 |
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| 作者单位： | 首都医科大学宣武医院内分泌科 |
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| 摘 要： | 利用序列特异性寡核苷酸引物多聚酶链反应 (PCR/SSP)的方法 ,对北方汉族 4 2例Grave病患者及 52例正常对照组的HLA DR2、DR3的分布频率进行了分析。结果 :Grave病患者组HLA DR3抗原的频率明显高于正常对照组 (P <0 .0 5) ,相对危险度为 3.84 ,而HLA DR2抗原的频率在 2组间无明显差异 (P >0 .0 5)。提示 :HLA DR3与北方汉族Grave病的发病有相关性。
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| 关 键 词： | Grave病 组织相容性白细胞抗原(HLA) 多聚酶链反应(PCR) 序列特异性寡核苷酸引物(SSP) |
| 收稿时间： | 1999-06-20 |
The Study of Grave Disease Associated with HLA in Northern Han Chinese |
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| Lu Meihua,Shao Wenshuo. The Study of Grave Disease Associated with HLA in Northern Han Chinese[J]. Journal of Capital Medical University, 2000, 21(2): 122-124 |
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| Authors: | Lu Meihua Shao Wenshuo |
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| Affiliation: | Department of endocrine, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences |
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| Abstract: | Northern Han Chinese patients with Grave disease and 52 healthy controls were randomly chosen. Ploymerase chain reaction and sequence specific primer (PCR/SSP) were used to determine the frequency of HLA DR2 and DR3. The frequency of DR3 was increased in Grave disease patients, the relative risk ( RR ) was 3.84( P <0.05). The RR of DR2 was 1.16( P >0.05). The above results suggested that HLA DR3 is associated with Grave disease in Northern Han Chinese. |
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| Keywords: | Grave disease HLA PCR SSP |
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