| 河豚毒素诱发小鼠骨髓细胞染色体畸变、小鼠骨髓细胞微核及小鼠精子畸变的研究 |
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| 引用本文： | 于丽华,周力,谢克勤.河豚毒素诱发小鼠骨髓细胞染色体畸变、小鼠骨髓细胞微核及小鼠精子畸变的研究[J].山东大学学报(医学版),2000,38(1). |
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| 作者姓名： | 于丽华 周力 谢克勤 |
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| 作者单位： | 1. 山东医科大学毒理学省级重点实验室
2. 济南长虹医院 |
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| 摘 要： | 目的 :探讨河豚毒素 ( TTX)的药用价值 ,检测其是否有潜在的致突变作用。方法 :采用小鼠精子畸变试验、小鼠骨髓细胞微核试验和染色体畸变试验进行观察。结果 :河豚毒素未引起小鼠骨髓嗜多染红细胞微核率、小鼠精子畸变率和小鼠骨髓细胞染色体畸变率增加 ,与阴性对照组比较无显著性差异 ( P>0 .0 5) ,但 3项试验的阳性对照组与阴性对照组比较 ,则有高度显著性差异 ( P<0 .0 1 )。 结论 :提示 TTX无致突变性。
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| 关 键 词： | 河豚毒素 骨髓细胞 染色体 微核 精子 小鼠 |
STUDY ON CHROMOSOME ABERRATION AND MICRONUCLEUS IN BONE MARROW CELLS OF MICE AND SPERM ABNORMALITY OF MICE INDUCED BY TETRODOTOXIN |
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| YU Li-hua,ZHOU Li,XIE Ke-qin.STUDY ON CHROMOSOME ABERRATION AND MICRONUCLEUS IN BONE MARROW CELLS OF MICE AND SPERM ABNORMALITY OF MICE INDUCED BY TETRODOTOXIN[J].Journal of Shandong University:Health Sciences,2000,38(1). |
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| Authors: | YU Li-hua ZHOU Li XIE Ke-qin |
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| Abstract: | Objective: To explore whether Tetrodotoxin has medical values and find out if it has potential mutagenic actions.Methods: Sperm abnormality test, chromosome aberration test of bone marrow cells and micronucleus test of bone marrow polychromalic erythrocytes(PCE) in mice were adopted.Results: There were no significant findings in sperm abnormality rates, chromosome aberration and micronucleas rates in experimental groups compared with those of the negative control group(P>0.05) while the rates in the positive control group showed significant increase(P<0.01).Conclusion: Tetrodotoxin might be regarded as a nonmutagenic agent under present experimental conditions. |
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| Keywords: | Tetrodotoxin Bone marrow cells Chromosomes Micronuclei Spermatozoa Mice |
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