氢氧化铝致猫慢性局限性癫痫模型的研究

为研究氢氧化铝在猫慢性局限性癫痫形成中的作用 ,在猫运动区皮质注射不同剂量的氢氧化铝乳剂后 ,观察不同时间内其行为、脑电图的改变 ,并进行组织病理学分析。结果表明在运动区皮质注射氢氧化铝可引起注射部位损伤及动物脑电图的异常改变 ,剂量不同 ,损伤程度也不同 ,但均未发现连续性癫痫发作 ,也未观察到有否偶发。提示 ,氢氧化铝可造成猫脑电图的异常改变 ,但作为慢性局限性实验癫痫模型尚有待研究。

Alumina Cream-induced Focal Motor Epilepsy in Cats

Various dosages of alumina cream were spectively injected into the unilateral motor areas in cats in order to study its effect on the development of chronic focal epilepsy. The changes of cats′ behaviors, histological analysis and electroencephalographic(EEG) were observed from two to four months. Histological analysis showed that alumina cream produced an epileptic foci. Spikes were recorded easily during EEG monitoring when injection dosage was increased to 100～150 μL. But none of the cats were observed to occur spontaneous seizures. These results indicated that alumina cream could induced the abnormal changes of EEG in cats, however, because spontaneous seizures were less predicatable and were not observed, the reliability of this preparation in cats as a model of chronic focal epilepsy was debatable.