唾液酸化的路易斯寡糖-X抗原检测在大肠癌原发灶及转移灶中的表达及其意义

目的 探讨唾液酸化的路易斯寡糖-X (sLex)抗原在大肠癌及大肠癌肝转移病人中表达的临床意义。方法 应用LSAB法检测原发性大肠癌及大肠癌肝转移灶中sLex抗原的表达。结果 在原发性大肠癌中，sLex抗原染色阳性率为100%，其中高分化腺癌sLex抗原表达呈弱阳性，低分化腺癌sLex抗原表达呈阳性或强阳性；在大肠癌肝转移灶中，sLex抗原染色阳性率为100%，肝转移灶中sLex抗原的表达强于原发灶中sLex抗原的表达。结论 sLex抗原的检测可作为大肠癌肝转移及预后指标，对判断大肠癌肝转移及估价预后有重要意义。

Expression and significance of sLex antigen in primary lesion and liver metastases from colorectal cancer

Objective To explore the clinical significance of the expression of sialyl Lewis-X (sLex) antigen in the patients with primary colorectal cancer or colorectal liver metastases. Methods The expression of sLex antigen was detected in both primary tumors and matched metastatic liver lesion of colorectal cancer using immunohistochemical method. Results In primary colorectal cancer, the positive expression ratio of sLex antigen was 100%. It was found that the poorly differentiated tumor cells expressed higher sLex antigen than moderately or well-differentiated ones and the expression of sLex antigen was more intense in liver metastases than in primary lesion. Conclusions SLex antigen can be used as a marker for indicating early liver metastasis of colorectal cancer and its prognosis, and its detection plays a significant role in judging liver metastasis and evaluating the prognosis of colorectal cancer.