2型糖尿病患者并发心血管病变与血小板平均体积的关系

目的探讨2型糖尿病(T2DM)患者并发心血管病变与血小板平均体积(MPV)的关系。方法选取2013年12月至2015年12月医院109例T2DM患者作为研究对象,其中47例合并心血管病变患者合并心血管病变组,62例未合并心血管病变患者作为未合并心血管病变组,选取同期医院体检正常者45例作为对照组,空腹静脉采血测定MPV、血小板计数(PLT)、血小板分布宽度(PDW)、糖化血红蛋白(HbAlc)、空腹血糖、高敏C反应蛋白(hs-CRP)、纤维蛋白原(Fbg)、D二聚体(D-D)水平。结果 T2DM合并心血管病变组、未合并心血管病变组HbAlc、空腹血糖均高于对照组(P0.05),T2DM合并心血管病变组、未合并心血管病变组组间比较无差异(P0.05);T2DM合并心血管病变组MPV、PDW、hs-CRP、Fbg、D-D明显高于未合并心血管病变组和对照组,PLT明显低于未合并心血管病变组和对照组(P0.05),未合并心血管病变组和对照组组间比较有差异(P0.05)。MPV与PDW(r=0.358,P=0.023)、hs-CRP(r=0.327,P=0.028)、Fbg(r=0.396,P=0.018)、D-D(r=0.674,P=0.001)呈正相关关系,与PLT(r=-0.417,P=0.009)呈负相关关系。结论 2型糖尿病患者并发心血管病变与MPV密切相关。

Relationship Between Cardiovascular Disease and mean Platelet Volume in Patients with Type 2 Diabetes Mellitus

Objective To investigate the relationship between cardiovascular disease and mean platelet volume(MPV) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 109 patients with T2DM who were admitted in the hospital between December 2013 and December 2015 were selected as study subjects,of whom 47 cases complicated with cardiovascular disease were included in the cardiovascular disease group,and 62 cases without cardiovascular disease were included in the non cardiovascular disease group.45 healthy people were selected as control group.Fasting venous blood was collected for determination of the levels of MPV,platelet count (PLT),platelet distribution width (PDW),hemoglobin A1 c (HbAlc),fasting blood glucose,high-sensitivity C reactive protein(hs-CRP),fibrinogen(Fbg),D-dimer(D-D).Results The levels of HbAlc and fasting blood glucose in T2DM with cardiovascular disease group and non cardiovascular disease group were higher than those in the control group (P ＜ 0.05).There was no significant difference between the T2DM with cardiovascular disease group and the non cardiovascular disease group (P ＞ 0.05);MPV,PDW,hs-CRP,Fbg and D-D in T2DM with cardiovascular disease group were significantly higher than those in non cardiovascular disease group and control group while PLT was significantly lower than that in non cardiovascular disease group and control group(P ＜ 0.05).There was significant difference between the non cardiovascular disease group and the control group(P ＜ 0.05).MPV are positively correlated with PDW(r =0.358,P =0.023),hs-CRP(r =0.327,P =0.028),Fbg(r =0.396,P =0.018)and D-D(r =0.674,P =0.001)while it was positively correlated with PLT(r =-0.417,P =0.009).Conclusion The occurrence of cardiovascular disease in patients with T2DM is closely related to MPV.