慢性阻塞性肺疾病患者静脉血栓的形成与血栓素A2、前列环素水平的关系研究及其护理

目的探讨慢性阻塞性肺疾病(COPD)患者静脉血栓的形成与血栓素A_2(TXA_2)、前列环素(PGI_2)水平的关系研究及其护理。方法选取我院老年病科2013年10月~2015年3月收治的120例COPD患者作为研究对象。依据COPD患者不同时期以及是否伴有静脉血栓进行分为2组,A组(58例):COPD不伴静脉血栓者,B组(62例):COPD伴静脉血栓者。同时选择60例同期的健康体检者作为对照组C组。比较各组患者TXA_2、PGI_2水平变化情况,以及COPD的护理对策。结果与C组相比,A组、B组TXA_2水平升高,PGI_2水平降低,TXA_2/PGI_2比值升高,差异均具有统计学意义(P0.05)。与A组相比,B组TXA_2水平升高,PGI_2水平降低,TXA_2/PGI_2比值升高,差异均具有统计学意义。与缓解期相比,急性期COPD伴静脉血栓患者的TXA_2水平升高,PGI_2水平降低,TXA_2/PGI_2比值升高,差异均具有统计学意义(P0.05)。结论COPD患者静脉血栓的形成与TXA_2、PGI_2水平密切相关,临床上应加强预防COPD患者静脉血栓的形成与护理。

Relationship between theLevels of TXA2 , PGI2 and Venous Thrombosis in Patients with Chronic Obstructive Pulmonary Disease and Nursing

Objective To study the relationship between the levels of TXA 2 , PGI2 and venous thrombosis in patients with chronic obstructive pulmonary disease ( COPD ) and nursing countermeasures . Methods 120 cases patients with COPD in our hospital from 2013 October to 2015 March were chose,and were divided into two groups .A group,58 cases,was COPD but not venous thrombosis .B group,62 cases,was COPD and venous thrombosis .Another 60 normal persons were chose to be control group ( C group ) .The relationship between the levels of TXA 2 , PGI2 and venous thrombosis in patients with chronic obstructive pulmonary disease ( COPD) and nursing countermeasures were evaluated in each group .Results Compared with C group,the levels of TXA2 were obviously higher ,the levels of PGI2 were obviously lower ,the rate of TXA2/PGI2 were obviously higher in A,B groups(P<0.05).Compared with A group,the levels of TXA2 were obviously higher,the levels of PGI2 were obviously lower,the rate of TXA2/PGI2 were obviously higher in B group(P<0.05).Compared with the remission,the levels of TXA2 were obviously higher,the levels of PGI2 were obviously lower,the rate of TXA2/PGI2 was obviously higher in acute phase in B group (P <0.05). Conclusion The levels of TXA2 ,PGI2 are with the relevant of venous thrombosis in patients with COPD .We should make important on nursing on COPD patients with venous thrombosis .