创伤性休克患者黏附分子的变化及意义 |
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引用本文: | 陈荣剑,林洪武,彭咏梅,黄宗海. 创伤性休克患者黏附分子的变化及意义[J]. 广西医科大学学报, 2009, 26(4): 524-526 |
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作者姓名: | 陈荣剑 林洪武 彭咏梅 黄宗海 |
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作者单位: | 中国人民解放军第184医院外科,鹰潭,335000;南方医科大学附属珠江医院普外科,广州,510282 |
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基金项目: | 南京军区医学科学技术研究"十一五"计划课题 |
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摘 要: | 目的:探讨创伤性休克患者血清与脏器黏附分子P-选择素的变化及意义。方法:采用酶联免疫法(ELISA)测定血清中P-选择素变化,同时采用免疫组织化学方法(SABC法)检测患者(骨骼肌、脾脏、小肠)P-选择素的表达。结果:正常对照组血清中P-选择素即有表达,创伤休克患者血清及脏器中P-选择素含量明显升高。结论:创伤可导致P-选择素大量表达,这与创伤时存在明显的微循环紊乱和内皮功能障碍有关。
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关 键 词: | 创伤 P-选择素 黏附分子 |
ALTERATION AND SIGNIFICANCE OF ADHESION MOLECULE IN TRAUMATIC SHOCK PATIENTS |
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Affiliation: | Chen Rongjan, Lin Hongwu, Peng Yongmei, et al. (Department of Surgery, the 184th Hospital of the PLA,Yingtam 335000 China) |
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Abstract: | Objective:To investigate the alteration and significance of adhesion molecule(P selection) in serum and organs during traumatic shock. Methods:The serum P-selectin level was assayed by enzyme linked immunosorbent assay and P-selectin expression in organs including somatic muscles, spleen and small intesine was determined by means of streptavidin-biotin immunocytochemical staining technique. Result:The Pselectin was expressed in normal control. The level of P-selectin was significantly increased in traumatic shock patients. Conclusion:The level of P-selectin is expressed in great quantity during tranma. It is related to the marked microcirculatory disturbance and endothelial dysfunction. |
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Keywords: | trauma shock adhesion molecule P-selectin |
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