| 创伤性休克患者黏附分子的变化及意义 |
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| 引用本文： | 陈荣剑,林洪武,彭咏梅,黄宗海.创伤性休克患者黏附分子的变化及意义[J].广西医科大学学报,2009,26(4):524-526. |
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| 作者姓名： | 陈荣剑 林洪武 彭咏梅 黄宗海 |
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| 作者单位： | 1. 中国人民解放军第184医院外科,鹰潭,335000
2. 南方医科大学附属珠江医院普外科,广州,510282 |
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| 基金项目： | 南京军区医学科学技术研究"十一五"计划课题 |
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| 摘 要： | 目的：探讨创伤性休克患者血清与脏器黏附分子P-选择素的变化及意义。方法：采用酶联免疫法（ELISA）测定血清中P-选择素变化,同时采用免疫组织化学方法（SABC法）检测患者（骨骼肌、脾脏、小肠）P-选择素的表达。结果：正常对照组血清中P-选择素即有表达,创伤休克患者血清及脏器中P-选择素含量明显升高。结论：创伤可导致P-选择素大量表达,这与创伤时存在明显的微循环紊乱和内皮功能障碍有关。
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| 关 键 词： | 创伤 P-选择素 黏附分子 |
ALTERATION AND SIGNIFICANCE OF ADHESION MOLECULE IN TRAUMATIC SHOCK PATIENTS |
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| Institution: | Chen Rongjan, Lin Hongwu, Peng Yongmei, et al. (Department of Surgery, the 184th Hospital of the PLA,Yingtam 335000 China) |
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| Abstract: | Objective：To investigate the alteration and significance of adhesion molecule（P selection） in serum and organs during traumatic shock. Methods：The serum P-selectin level was assayed by enzyme linked immunosorbent assay and P-selectin expression in organs including somatic muscles, spleen and small intesine was determined by means of streptavidin-biotin immunocytochemical staining technique. Result：The Pselectin was expressed in normal control. The level of P-selectin was significantly increased in traumatic shock patients. Conclusion：The level of P-selectin is expressed in great quantity during tranma. It is related to the marked microcirculatory disturbance and endothelial dysfunction. |
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| Keywords: | trauma shock adhesion molecule P-selectin |
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