Increased Expression of Plasma and CD4+ T Lymphocyte Costimulatory Molecule CD26 in Adult Patients with Allergic Asthma |
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| Authors: | Samantha W M Lun C K Wong Fanny W S Ko David S C Hui Christopher W K Lam |
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| Institution: | (1) Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong;(2) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong;(3) Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong |
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| Abstract: | CD26, which is a costimulatory molecule and peptidase, is responsible for the degradation of interferon (IFN)-γ-induced chemokines. To elucidate the immunopathological role of CD26 in allergic asthma, we investigated plasma soluble CD26
(sCD26) concentration and its cell surface expression on lymphocytes, monocytes, CD4+ T helper, CD8+ T suppressor plus cytotoxic
T, invariant natural killer T (iNKT), and CD19+ B lymphocytes in allergic asthmatic patients. Plasma sCD26 was significantly
elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface expression of CD26 was significantly up-regulated on lymphocytes, especially on CD4+ and iNKT lymphocytes
(all P < 0.05), but not on other cell types. Significant positive correlations were found between sCD26 and the percentage of eosinophils,
Th2-related chemokines CCL5 and CCL22, and costimulatory molecule sCTLA-4 (all P < 0.05). In conclusion, the aberrant expression of CD26 may contribute to the inflammatory process and Th2 predominance in
the immunopathogenesis of allergic asthma.
Equal first authors |
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| Keywords: | allergy asthma costimulatory molecules CD26 T lymphocytes |
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