乙丁型肝炎病毒感染树鼠句肝组织Fas和ICE的表达

目的探讨乙型并丁型肝炎病毒感染树鼠句肝组织中Fas和ICE表达与HDV感染之间的关系。方法采用免疫组织化学技术对45份HDV/HBV感染树鼠句肝组织中HDAg、Fas和ICE的表达进行了检测。结果45份肝组织中有39份可检出Fas(阳性率86.7%)，有43份可检出ICE(阳性率95.6%)。Fas和ICE在肝细胞质和(或)膜上表达，以肝细胞质内表达为主。HDAg表达与Fas和ICE表达之间有显著相关性(χ2值为29.2和36.2，P＜0.01)，HDAg表达越强，Fas和ICE表达也越强。结论肝细胞内的HDAg表达可诱导Fas和ICE的表达。

Fas and ICE expression in the hepatocytes of tupaia with HDV/HBV infection

Objective To investigate the relationship between Fas and ICE expression and HDV infection. Methods HDAg, Fas, and ICE were determined in 45 liver tissue specimens of tupaia with HDV/HBV infection by immunohistochemistry. Results Fas was detected in 39 out of 45 liver tissue specimens (86.7%), and ICE in 43 (95.6%). Fas and ICE were located in the cytoplasm or/and the membrane of hepatocytes, especially in the cytoplasm. There was significant correlation between the expression of HDAg and the expression of Fas and ICE (x2=29.2 and 36.2, respectively, P <0.01). Conclusions The expression of Fas and ICE may be induced by HDAg in hepatocytes.