肥大细胞对特发性眼眶炎性假瘤纤维化的作用研究 |
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引用本文: | 曾祥云,袁思奇,刘琳琳,谭述香,谢招莲,黄彬红,高艳芳. 肥大细胞对特发性眼眶炎性假瘤纤维化的作用研究[J]. 赣南医学院学报, 2014, 0(4): 491-493 |
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作者姓名: | 曾祥云 袁思奇 刘琳琳 谭述香 谢招莲 黄彬红 高艳芳 |
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作者单位: | 曾祥云 (赣南医学院 第一附属医院,江西 赣州,341000); 袁思奇 (赣南医学院 第一附属医院,江西 赣州,341000); 刘琳琳 (赣南医学院 第一附属医院,江西 赣州,341000); 谭述香 (赣南医学院 第一附属医院,江西 赣州,341000); 谢招莲 (赣南医学院 第一附属医院,江西 赣州,341000); 黄彬红 (赣南医学院 第一附属医院,江西 赣州,341000); 高艳芳 (赣南医学院 第一附属医院,江西 赣州,341000); |
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基金项目: | 江西省自然科学基金资助项目,项目编号:20114BAD205068 |
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摘 要: | 目的:探讨肥大细胞在特发性眼眶炎性假瘤纤维化中的作用。方法:将分离纯化的大鼠骨髓肥大细胞和同源大鼠眼眶成纤维细胞,分别进行单独和共育培养。观察肥大细胞和成纤维细胞共育对成纤维细胞在形态和数量上的影响。结果:肥大细胞和成纤维细胞共育能够显著增强成纤维细胞的增殖活性,共育组中单位面积内的成纤维细胞数较对照组显著增加,差异具有统计学意义P﹤0.01)。结论:肥大细胞对眼眶成纤维细胞的增殖具有显著的促进作用,提示其在特发性眼眶炎性假瘤纤维化过程中发挥着重要作用。
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关 键 词: | 特发性眼眶炎性假瘤 肥大细胞 成纤维细胞 |
Role of Mastocyte in the Fibrillation of Idiopathic Orbital Inflammatory Pseudotumor |
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Affiliation: | ZENG Xiang-yun, YUAN Si-qi, LIU Lin-lin, TAN Shu-xiang, XIE Zhao-lian, HUANG Bin-hong, GAO Yan-fang ( 1. the First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi 341000) |
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Abstract: | Objective:To investigate the role of mastocyte(MC)in the proliferation of fibroblast in Idiopathic Orbital In-flammatory Pseudotumor(IOIP). Methods:Rat bone marrow mastocyte and fibroblast were separated and purified,and then cultured them together and respectively. Cell morphology and cell number were observed and analyzed to investigate the role of MC in the proliferation of fibroblast. Results:Proliferation of fibroblast was significantly enhanced by culturing together with MC and cell number of MC was also significantly increased during compound culturing. There was statisti-cally significant difference(P ﹤ 0. 01). Conclusion:MC significantly promotes the proliferation of fibroblast and plays a crucial role during fibrillation in IOIP. |
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Keywords: | Idiopathic Orbital Inflammatory Pseudotumor mastocyte fibroblast |
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