| 尼尔雌醇对去卵巢大鼠生殖道的影响 |
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| 关 键 词： | 尼尔雌醇 大鼠 子宫内膜 围绝经期 绝经后 |
Effects of Nilestriol on reproductive system in ovariectomized rats] |
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| H Liu,K Xu,J Tan,S Yang. Effects of Nilestriol on reproductive system in ovariectomized rats][J]. Journal of West China University of Medical Sciences, 2000, 31(1): 65-67 |
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| Authors: | H Liu K Xu J Tan S Yang |
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| Affiliation: | Department of Obstetrics and Gynecology, Second Affiliated Hospital, WCUMS, Chengdu 610041. |
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| Abstract: | The purpose of this study was to determine the effects of Nilestriol on reproductive system. Female SD rats, aged 4 months, were randomly divided into three groups. The OVX group's rats were subjected to bilateral ovariectomy, the SHAM group's rats received sham surgery; the Nilestriol(CEE3) group's rats were subjected to bilateral ovariectomy and treated with CEE3(0.15 mg/100 g BW, once a week). A computerized image analyzer was used to evaluate the endometrial pathological changes 10 weeks later. The weight of uterus was measured. The results showed that in OVX group, atrophic uteri; and atrophied endometria were noted. The weight of uterus was increased in CEE3 group, compared with that in OVX group (642.20 +/- 283.60 mg vs. 297.00 +/- 106.90 mg, P < 0.05). The volume fraction of endometrial glands was also significantly elevated in CEE3 group, compared with that in OVX group (1.84% vs 0.58%). The endometria in CEE3 group were at an early proliferative stage. These suggest that Nilestriol has a slight stimulating effect on the uteri of ovariectomized rats, including their endometria and uterine smooth muscles. Nilestriol is suited to be used in combination with progestogen. |
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