| 内皮素-1及其受体在良性前列腺增生中的表达研究 |
| |
| 作者单位： | 南京医科大学附属南京第一医院泌尿外科，南京医科大学附属南京第一医院泌尿外科，南京师范大学生命科学院，南京医科大学附属南京第一医院泌尿外科，南京医科大学附属南京第一医院泌尿外科，南京医科大学附属南京第一医院病理科 |
| |
| 摘 要： | 目的探讨内皮素-1及其受体(ETAR与ETBR)在良性前列腺增生(BPH)移行区组织中表达的意义。方法采用免疫组化及Western blot技术检测5例正常前列腺组织(NP)与16例BPH组织中内皮素-1及其受体表达情况。结果BPH移行区组织中内皮素-1阳性面积为(77936.16±85291.33)μm2,ETAR积分吸光度为316.6±65.2,明显高于正常前列腺组织(阳性面积75.68±110.85μm2,ETAR积分吸光度为140.2±64.8),而2组ETBR的表达(积分吸光度分别为81.4±31.8,105.0±45.5)差异无统计学意义。结论BPH移行区组织中内皮素-1及其ETAR表达上调,在BPH的病理生理过程中可能产生重要作用。
|
| 关 键 词： | 良性前列腺增生 内皮素-1 内皮素受体 |
Endothelin-1 and its receptors expression in the prostatic tissues of patients with benign prostatic hyperplasia |
| |
| JIA Rui-peng,XU Lu-wei,WEN Chuan-jun,SU Jiang-hao,LIU Jun,WANG Jin-song. Endothelin-1 and its receptors expression in the prostatic tissues of patients with benign prostatic hyperplasia[J]. Chinese Journal of Urology, 2006, 0(Z2) |
| |
| Authors: | JIA Rui-peng XU Lu-wei WEN Chuan-jun SU Jiang-hao LIU Jun WANG Jin-song |
| |
| Affiliation: | JIA Rui-peng,XU Lu-wei,WEN Chuan-jun,SU Jiang-hao,LIU Jun,WANG Jin-song. Department of Urology,Nanjing First Hospital Affiliated to Nanjing Medical University,Nanjing,210006,China |
| |
| Abstract: | Objective To elucidate endothelin-1 and its receptors expression in benign prostatic hyperplasia (BPH), and to explore the role of ET-1 in the pathogenesis of BPH. Methods detect the expression of ET-1 by immunohistochemistry and the protein of ETAR and ETBR by Western blot in 16 samples of BPH and 6 samples of normal prostate. Results Positive ET-1 was detected in basal epithelial cells and secretory cells of the glandular epithelium of the samples of BPH. The expression of ETAR of BPH was significantly higher than the control. Conclusions The effect of endothelin was prominently mediated by the ETA receptor .These results suggest that ET-1 and ETAR may play functional roles in benign prostatic hyperplasia. |
| |
| Keywords: | Benign prostatic hyperplasia Endothelin-1 Endothelin receptor |
| 本文献已被 CNKI 等数据库收录！ |
|
