| 整合素与冠脉介入治疗后再狭窄 |
| |
| 引用本文： | 胡文兰,乔树宾. 整合素与冠脉介入治疗后再狭窄[J]. 心血管病学进展, 2007, 28(3): 389-392 |
| |
| 作者姓名： | 胡文兰 乔树宾 |
| |
| 作者单位： | 中国医学科学院,中国协和医科大学,心血管病研究所,阜外心血管病医院,北京,100037 |
| |
| 摘 要： | 整合素是细胞表面介导细胞-细胞间以及细胞-细胞外基质间黏附作用的主要黏附分子。整合素通过介导血栓形成、炎症反应、血管平滑肌细胞迁移增殖等多种机制参与冠脉介入治疗后再狭窄的发生、发展和形成。拮抗整合素能抑制再狭窄的形成,这可能成为开发防治再狭窄新药的方向。
|
| 关 键 词： | 整合素 细胞外基质 冠心病 再狭窄 |
| 文章编号： | 1004-3934(2007)03-0389-04 |
| 修稿时间： | 2006-01-10 |
Integrin and Restenosis after Percutaneous Coronary Intervention |
| |
| HU Wen-lan,QIAO Shu-bin. Integrin and Restenosis after Percutaneous Coronary Intervention[J]. Advances in Cardiovascular Diseases, 2007, 28(3): 389-392 |
| |
| Authors: | HU Wen-lan QIAO Shu-bin |
| |
| Affiliation: | Department of Cardiology, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Science and Peking Union Medical College, Belting 100037, China |
| |
| Abstract: | Integrins are an important family of cell surface receptors that mediate the adhesion of cells to each other and to the extracellular matrix.Integrins can also facilitate the progression of restenosis after percutaneous coronary intervention involving thrombosis,inflammation,migration and proliferation of vascular smooth muscle cells.Antagonists of integrins could inhibit the development of restenosis,which might provide insight into the use of new drugs to treat restenosis. |
| |
| Keywords: | integrin extracellular matrix coronary heart disease restenosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
