换血疗法治疗不同胎龄新生儿高胆红素血症的临床研究

目的:探讨换血疗法治疗不同胎龄新生儿高胆红素血症的疗效及副作用。方法:将1991～2004年进行换血的56例新生儿按照胎龄分组,分析其疗效和副作用有无差异。结果:两组患儿换血后胆红素水平均显著降低(P<0.001)。早产儿换血后更易发生内环境紊乱,但差异无统计学意义(P>0.05)。结论:换血疗法治疗不同胎龄新生儿高胆红素血症疗效确切,尽管其所致的副作用如血生化异常、酸中毒、血小板减少症等通常可自我调节,但对早产儿而言仍不容忽视。

Clinic study of exchange tansfusion on neonatal with hyperbilirubinemia at different gestational age

Objective:To investigate the curative effect and incidence of adverse events attributable to exchange transfusion performed for neonatal hyperbilirubinemia.Methods:56 infants treated by exchange transfusion in 1991~2004 were divided into 2 groups according to gestational age to compare the curative effect and incidence of adverse events.Results:After exchange transifusion, the level of serum bilirubin decreased prominently in any group (P<0.001 ), and the abnormal rates of internal milieu was much more in preterm group than that in term group, but having no significance (P>0.05).Conclusion:Exchange transfusion is effective for the treatment of hyperbilirubinemia in neonates with different gestational age. Its side effects, including disturbance in blood electrolyte balance, acidosis or thrombocytopenia, might be corrected by auto-modification, but still should not be neglected in preterm babies.