| HPLC法测定丹参片中4种丹参酮类成分的含量 |
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| 引用本文： | 秦学玲,秦兴卫,马娜,蒋新平,杨璐璐. HPLC法测定丹参片中4种丹参酮类成分的含量[J]. 西北药学杂志, 2019, 0(4): 487-491 |
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| 作者姓名： | 秦学玲 秦兴卫 马娜 蒋新平 杨璐璐 |
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| 作者单位： | 1.云南省食品药品监督检验研究院;2.昆明赛诺制药股份有限公司;3.云南百康药业有限公司;4.中国人民解放军联勤保障部队第九二〇医院 |
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| 基金项目： | 全军中医药重大专项课题项目(编号:2006071001) |
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| 摘 要： | 目的采用HPLC法同时测定8个厂家74批次丹参片中4种丹参酮类成分二氢丹参酮、丹参酮Ⅰ、隐丹参酮和丹参酮ⅡA的含量。方法采用HPLC法,AglientZORBAXC18色谱柱(250mm×4.6mm,5μm);流动相:甲醇-1mL·L^-1磷酸溶液(80∶20);柱温:30℃;流速:1mL·min^-1;检测波长:270nm。结果二氢丹参酮、丹参酮Ⅰ、隐丹参酮和丹参酮ⅡA的进样量分别在1.956~97.8,3.820~191.0,4.982~249.1和5.440~272.0ng范围内与色谱峰峰面积呈良好的线性关系;平均回收率(n=6)分别为99.7%,100.0%,99.9%和99.9%,RSD值分别为0.51%,0.00%,0.30%和0.21%。结论建立的HPLC法简便快捷、准确,重复性好,可作为丹参片的质量控制方法。
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| 关 键 词： | HPLC法 丹参片 二氢丹参酮 丹参酮Ⅰ 隐丹参酮 丹参酮ⅡA |
Content determination of 4 tanshinones in Danshen Tablets by HPLC |
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| QIN Xueling,QIN Xingwei,MA Na,JIANG Xinping,YANG Lulu. Content determination of 4 tanshinones in Danshen Tablets by HPLC[J]. Northwest Pharmaceutical Journal, 2019, 0(4): 487-491 |
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| Authors: | QIN Xueling QIN Xingwei MA Na JIANG Xinping YANG Lulu |
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| Affiliation: | (The Food and Drug Supervision and Inspection Institute in Yunnan Province,Kunming 650011,China;Kunming Sainuo Pharmaceutical Limited Company,Kunming 650011,China;Yunnan Baikang Pharmaceutical Limited Company,Kunming 650106,China;The 920th Hospital of the Joint Logistic Support Force of the Chinese People′s Liberation Army,Kunming 650032,China) |
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| Abstract: | QIN Xueling;QIN Xingwei;MA Na;JIANG Xinping;YANG Lulu(The Food and Drug Supervision and Inspection Institute in Yunnan Province,Kunming 650011,China;Kunming Sainuo Pharmaceutical Limited Company,Kunming 650011,China;Yunnan Baikang Pharmaceutical Limited Company,Kunming 650106,China;The 920th Hospital of the Joint Logistic Support Force of the Chinese People′s Liberation Army,Kunming 650032,China) |
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| Keywords: | HPLC Danshen Tablets dihydrotanshinone tanshinoneⅠ cryptotanshinone tanshinoneⅡA |
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