The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury |
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| Authors: | Zhi-Qiang Feng Ying-Yu Wang Feng-Ming Chu Piao-Yang Sun |
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| Affiliation: | 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education &2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 100050, China;3. Hengrui Pharmaceutical Company , Lianyungang, 222002, China |
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| Abstract: | Puerarin is a naturally occurring isoflavone and is frequently used for the treatment of cardiovascular symptoms in China. By the structural modification of the puerarin molecule at different positions, seven new puerarin derivatives were obtained, and their cardioprotective activities (in vitro and in vivo) were respectively evaluated. The finding that the activities of 3 and 8 markedly exceeded puerarin suggested that the acylated modification of phenolic hydroxyl at C-7 in the puerarin molecule may improve the cardioprotective activity, which will be an important reference for further structural optimization. |
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| Keywords: | puerarin derivatives myocardial ischemia reperfusion injury |
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