Dibenzocyclooctadiene lignans from Kadsura coccinea |
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| Authors: | Wen Hu Long Li Qiong Wang Yong Ye Jie Fan Hai-Xia Li |
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| Institution: | 1. College of Pharmacy, Soochow University , Suzhou , 215123 , China;2. Jiangsu Yew Pharmaceutical Co., Ltd , Wuxi , 214199 , China;3. College of Pharmacy, Nihon University , 7-7-1 Narashinodai, Funabashi, Chiba , 274-8555 , Japan |
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| Abstract: | In vitro anti-allergic screening of medicinal herbal extracts revealed that the EtOAc extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ activated murine macrophage-like cell line, RAW264.7. Further fractionation of the EtOAc extract led to the isolation of two new dibenzocyclooctadiene lignans kadsuralignan G (1) and kadsuralignan L (2), and three known analog compounds. The absolute stereostructures were established by circular dichroism spectra. Both 1 and 2 showed moderate NO production inhibitory activities. |
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| Keywords: | Kadsura coccinea dibenzocyclooctadiene lignans NO production inhibitory activities |
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