Anti-inflammatory and antiproliferative prenylated chalcones from Hedysarum gmelinii |
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Authors: | Yi Liu Jun Zhang Ran Wen Guang-Zhong Tu Hu-Biao Chen |
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Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Baiyunshan Pharmaceutical General Factory, Guangzhou Baiyunshan Pharmaceutical Holdings Co. Ltd, Guangzhou 510515, China;3. Beijing Institutes of Microchemistry, Beijing 100091, China;4. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China |
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Abstract: | AbstractFive new prenylated chalcones hedysarumines C-G (1–5), along with eight known chalcones (6–13) all of which were isolated from the genus Hedysarum for the first time, were isolated from the roots of Hedysarum gmelinii by chromatographic methods. Their structures were determined by extensive spectroscopic techniques. The isolated chalcones (2–13) and previously isolated prenylated chalcones (14–16) were evaluated for antiproliferative activity against five human cancer cell lines (HepG2, A549, Du145, BGC823, and HCT116) and in vitro anti-inflammatory activity. Compounds 5, 10, and 15 inhibited NO production induced by lipopolysaccharide in BV-2 cells, with IC50 values ranging from 3.25 to 8.48 μM. Compounds 4 and 11 showed moderate antiproliferative activity to selective human cancer cell lines, with the IC50 values of 4 and 11 against A549 cell line being 7.79 and 9.67 μM, respectively, and the IC50 value of 11 against HCT116 cell line being 8.85 μM. |
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Keywords: | Leguminosae Hedysarum gmelinii prenylated chalcones anti-inflammatory activity antiproliferative activity |
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