Harzianums A and B produced by a fungal strain,Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines |
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| Authors: | H.-Z. Jin J.-H. Lee W.-D. Zhang H.-B. Lee Y.-S. Hong Y.-H. Kim |
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| Affiliation: | 1. School of Pharmacy, Shanghai, Jiao Tong University , Shanghai, 200240, China kimhz@sjtu.edu.cu;3. Korea Research Institute of Bioscience &4. Biotechnology , P.O. Box 115, Daejeon, 305-333, Yuseong, Korea;5. School of Biological Sciences, Seoul National University , Kwanak-gu, 151-742, Korea;6. College of Pharmacy, Chungnam National University , Daejeon, 305-764, Korea |
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| Abstract: | A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various 1H NMR and 13C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2′, 4′, 6′-octatriendioic acid esterified on the 4β-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer cell lines. |
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| Keywords: | Harzianum B Hypocrea sp Cytotoxicity Tumor cell lines |
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